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Evaluation of contrast-enhanced computed tomography for the differential diagnosis of hypovascular pancreatic neuroendocrine tumors from chronic mass-forming pancreatitis.
Ren, Shuai; Qian, Lichao; Daniels, Marcus J; Duan, Shaofeng; Chen, Rong; Wang, Zhongqiu.
Afiliación
  • Ren S; Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, Jiangsu Province, China; Department of Radiology, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518033, Guangdong Province, China; The First School of Clinical Medicine, Nanji
  • Qian L; The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China.
  • Daniels MJ; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Duan S; GE Healthcare, Shanghai 201203, China.
  • Chen R; Department of Diagnostic Radiology and Nuclear Medicine, School of Medicine, University of Maryland, Baltimore, MD, 21201, USA.
  • Wang Z; Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, Jiangsu Province, China; Department of Radiology, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518033, Guangdong Province, China. Electronic address: zhongqiuwang0815@163.com
Eur J Radiol ; 133: 109360, 2020 Dec.
Article en En | MEDLINE | ID: mdl-33126171
PURPOSE: To assess the role of contrast-enhanced computed tomography (CECT) for differentiation of hypovascular pancreatic neuroendocrine tumors (hypo-PNETs) from chronic mass-forming pancreatitis (CMFP). METHODS: A retrospective study of 59 patients (27 hypo-PNETs patients vs 32 CMFP patients) who underwent preoperative CECT between July 2012 and July 2019 was performed. Qualitative and quantitative analysis was performed, including mass location, size, margin, cystic changes, calcification, pancreatic or bile duct dilatation, pancreatic atrophy, local vessels involvement, mass contrast enhancement and mass-to-pancreas enhancement ratio. Multivariate logistic regression analyses were used to identify relevant CT imaging findings in differentiation between hypo-PNETs and CMFP. RESULTS: When compared to CMFP, hypo-PNETs more frequently had a well-defined margin and cystic changes and less frequently had a history of pancreatitis and calcification. CMFP had higher mass contrast enhancement and mass-to-pancreas enhancement ratio in the portal and delayed phases than hypo-PNETs. After multivariate logistic regression analyses, areas under the curve (AUCs) were 0.795 (95 % CI: 0.652-0.899), 0.752 (95 % CI: 0.604-0.866), 0.859 (95 % CI: 0.726-0.943), and 0.929 (95 % CI: 0.814-0.983) for Model 1(clinical factors), Model 2 (qualitative parameters), Model 3 (quantitative parameters), and their combinations, respectively. CONCLUSION: Combined assessment of clinical factors, qualitative, and quantitative imaging characteristics can improve the differentiation between hypo-PNETs and CMFP at CECT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Pancreatitis / Tumores Neuroendocrinos Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Qualitative_research Límite: Humans Idioma: En Revista: Eur J Radiol Año: 2020 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Pancreatitis / Tumores Neuroendocrinos Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Qualitative_research Límite: Humans Idioma: En Revista: Eur J Radiol Año: 2020 Tipo del documento: Article Pais de publicación: Irlanda