Targeting feed-forward signaling of TGFß/NOX4/DHFR/eNOS uncoupling/TGFß axis with anti-TGFß and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics.

Huang, Kai; Wang, Yongchen; Siu, Kin Lung; Zhang, Yixuan; Cai, Hua

Huang, Kai; Wang, Yongchen; Siu, Kin Lung; Zhang, Yixuan; Cai, Hua.

Afiliación

Huang K; Division of Molecular Medicine, Department of Anesthesiology, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Wang Y; Division of Molecular Medicine, Department of Anesthesiology, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Siu KL; Division of Molecular Medicine, Department of Anesthesiology, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Zhang Y; Division of Molecular Medicine, Department of Anesthesiology, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Cai H; Division of Molecular Medicine, Department of Anesthesiology, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: hcai@mednet.ucla.edu.

Redox Biol ; 38: 101757, 2021 01.

Article en En | MEDLINE | ID: mdl-33126053

Asunto(s)

Aneurisma de la Aorta; Tetrahidrofolato Deshidrogenasa; Animales; Células Endoteliales; Ácido Fólico; Ratones; NADPH Oxidasa 4/genética; Tetrahidrofolato Deshidrogenasa/genética; Factor de Crecimiento Transformador beta

Palabras clave

Abdominal aortic aneurysm (AAA); Dihydrofolate reductase (DHFR); Folic acid (FA); GTP cyclohydrolase 1 (GTPCHI); Marfan syndrome (MFS); NADPH oxidase (NOX); NOX isoform 4 (NOX4); Nitric oxide (NO); Reactive oxygen species (ROS); Tetrahydrobiopterin (H(4)B); Thoracic aortic aneurysm (TAA); Transforming growth factorß (TGFß); eNOS uncoupling/recoupling

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aneurisma de la Aorta / Tetrahidrofolato Deshidrogenasa Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Redox Biol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

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