A twist in the ABC: regulation of ABC transporter trafficking and transport by FK506-binding proteins.
FEBS Lett
; 594(23): 3986-4000, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-33125703
Post-transcriptional regulation of ATP-binding cassette (ABC) proteins has been so far shown to encompass protein phosphorylation, maturation, and ubiquitination. Yet, recent accumulating evidence implicates FK506-binding proteins (FKBPs), a type of peptidylprolyl cis-trans isomerase (PPIase) proteins, in ABC transporter regulation. In this perspective article, we summarize current knowledge on ABC transporter regulation by FKBPs, which seems to be conserved over kingdoms and ABC subfamilies. We uncover striking functional similarities but also differences between regulatory FKBP-ABC modules in plants and mammals. We dissect a PPIase- and HSP90-dependent and independent impact of FKBPs on ABC biogenesis and transport activity. We propose and discuss a putative new mode of transient ABC transporter regulation by cis-trans isomerization of X-prolyl bonds.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transportadoras de Casetes de Unión a ATP
/
Proteínas de Unión a Tacrolimus
Límite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2020
Tipo del documento:
Article
País de afiliación:
Suiza
Pais de publicación:
Reino Unido