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Extent of arterial calcification by conventional vitamin K antagonist treatment.
Hasific, Selma; Øvrehus, Kristian Altern; Gerke, Oke; Hallas, Jesper; Busk, Martin; Lambrechtsen, Jess; Urbonaviciene, Grazina; Sand, Niels Peter Rønnow; Nielsen, Jens Steen; Diederichsen, Louise; Pedersen, Kenneth Bruun; Carter-Storch, Rasmus; Ilangkovan, Nivethitha; Mickley, Hans; Rasmussen, Lars Melholt; Lindholt, Jes Sandal; Diederichsen, Axel.
Afiliación
  • Hasific S; Department of Cardiology, Odense University Hospital, Odense, Denmark.
  • Øvrehus KA; Department of Cardiology, Odense University Hospital, Odense, Denmark.
  • Gerke O; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.
  • Hallas J; Clinical Pharmacology and Pharmacy, University of Southern Denmark, Odense, Denmark.
  • Busk M; Department of Cardiology, Little Belt Hospital Vejle, Vejle, Denmark.
  • Lambrechtsen J; Department of Cardiology, Odense University Hospital Svendborg, Svendborg, Denmark.
  • Urbonaviciene G; Department of Cardiology, Regional Hospital Central Jutland Silkeborg, Silkeborg, Denmark.
  • Sand NPR; Department of Cardiology, Hospital South West Jutland Esbjerg, Esbjerg, Denmark.
  • Nielsen JS; DD2, Steno Diabetes Centre Odense, Odense University Hospital, Odense, Denmark.
  • Diederichsen L; OPEN, Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark.
  • Pedersen KB; Department of Rheumatology, Odense University Hospital, Odense, Denmark.
  • Carter-Storch R; Department of Cardiology, Odense University Hospital, Odense, Denmark.
  • Ilangkovan N; Department of Cardiology, Odense University Hospital Svendborg, Svendborg, Denmark.
  • Mickley H; Department of Internal Medicine, Little Belt Hospital Kolding, Kolding, Denmark.
  • Rasmussen LM; Department of Cardiology, Odense University Hospital, Odense, Denmark.
  • Lindholt JS; Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark.
  • Diederichsen A; Department of Cardiothoracic and Vascular Surgery, Odense University Hospital,Odense, Denmark.
PLoS One ; 15(10): e0241450, 2020.
Article en En | MEDLINE | ID: mdl-33119722
BACKGROUND AND AIMS: Vitamin K antagonists (VKA) remain the most frequently prescribed oral anticoagulants worldwide despite the introduction of non-vitamin K antagonist oral anticoagulants (NOAC). VKA interfere with the regeneration of Vitamin K1 and K2, essential to the activation of coagulation factors and activation of matrix-Gla protein, a strong inhibitor of arterial calcifications. This study aimed to clarify whether VKA treatment was associated with the extent of coronary artery calcification (CAC) in a population with no prior cardiovascular disease (CVD). METHODS: We collected data on cardiovascular risk factors and CAC scores from cardiac CT scans performed as part of clinical examinations (n = 9,672) or research studies (n = 14,166) in the period 2007-2017. Data on use of anticoagulation were obtained from the Danish National Health Service Prescription Database. The association between duration of anticoagulation and categorized CAC score (0, 1-99, 100-399, ≥400) was investigated by ordered logistic regression adjusting for covariates. RESULTS: The final study population consisted of 17,254 participants with no prior CVD, of whom 1,748 and 1,144 had been treated with VKA or NOAC, respectively. A longer duration of VKA treatment was associated with higher CAC categories. For each year of VKA treatment, the odds of being in a higher CAC category increased (odds ratio (OR) = 1.032, 95%CI 1.009-1.057). In contrast, NOAC treatment duration was not associated with CAC category (OR = 1.002, 95%CI 0.935-1.074). There was no significant interaction between VKA treatment duration and age on CAC category. CONCLUSIONS: Adjusted for cardiovascular risk factors, VKA treatment-contrary to NOAC-was associated to higher CAC category.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina K / Enfermedad de la Arteria Coronaria / Calcinosis / Anticoagulantes Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina K / Enfermedad de la Arteria Coronaria / Calcinosis / Anticoagulantes Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Estados Unidos