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Evaluation of the Toxicity of Two Electron-Deficient Half-Sandwich Complexes against Human Lymphocytes from Healthy Individuals.
Habas, Khaled; Soldevila-Barreda, Joan J; Azmanova, Maria; Rafols, Laia; Pitto-Barry, Anaïs; Anderson, Diana; Barry, Nicolas P E.
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  • Habas K; School of Chemistry and Biosciences, University of Bradford, Bradford, BD7 1DP, UK.
  • Soldevila-Barreda JJ; School of Chemistry and Biosciences, University of Bradford, Bradford, BD7 1DP, UK.
  • Azmanova M; School of Chemistry and Biosciences, University of Bradford, Bradford, BD7 1DP, UK.
  • Rafols L; School of Chemistry and Biosciences, University of Bradford, Bradford, BD7 1DP, UK.
  • Pitto-Barry A; School of Chemistry and Biosciences, University of Bradford, Bradford, BD7 1DP, UK.
  • Anderson D; School of Chemistry and Biosciences, University of Bradford, Bradford, BD7 1DP, UK.
  • Barry NPE; School of Chemistry and Biosciences, University of Bradford, Bradford, BD7 1DP, UK.
ChemMedChem ; 16(4): 624-629, 2021 02 17.
Article en En | MEDLINE | ID: mdl-33119178
Electron-deficient half-sandwich complexes are a class of under-studied organometallics with demonstrated potential as metallodrug candidates. This study investigates the effect of two 16-electron organoruthenium complexes ([(p-cym)Ru(benzene-1,2-dithiolato)] (1) and [(p-cym)Ru(maleonitriledithiolate)] (2)) on the cell viability of non-immortalised human lymphocytes from healthy individuals. The genotoxic effects of 1 and 2 in lymphocytes are also investigated by using the Comet and cytokinesis-block micronucleus assays. Gene expression studies were carried out on a panel of genes involved in apoptosis and the DNA damage-repair response. Results show that the two 16-electron complexes do not have significant effect on the cell viability of human lymphocytes from healthy individuals. However, an increase in DNA damage is induced by both compounds, presumably through oxidative stress production.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organometálicos / Linfocitos Límite: Humans Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organometálicos / Linfocitos Límite: Humans Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Alemania