Your browser doesn't support javascript.
loading
Association of risk factors and bleeding complications in Asian patients taking edoxaban.
Lee, Ok Sang; Kim, Woorim; Jang, Bo Min; Min, Kyung Hyun; Cho, Yoon Sook; Lee, Myung Koo; Lee, Kyung Eun.
Afiliación
  • Lee OS; College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.
  • Kim W; Department of Pharmacy, Seoul National University Hospital, Seoul, Republic of Korea.
  • Jang BM; College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.
  • Min KH; Department of Pharmacy, Seoul National University Hospital, Seoul, Republic of Korea.
  • Cho YS; College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.
  • Lee MK; Department of Pharmacy, Seoul National University Hospital, Seoul, Republic of Korea.
  • Lee KE; College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.
Br J Clin Pharmacol ; 87(4): 2121-2127, 2021 04.
Article en En | MEDLINE | ID: mdl-33118636
AIMS: Asian patients are known to be more prone to bleeding complications than patients of other ethnicities. Therefore, there are possibilities of other risk factors that should be given special consideration for dosage adjustment in this specific ethnic group. This study aimed to investigate the risk factors for bleeding complications in Asian patients under appropriate edoxaban dosage regimens. METHODS: Data on patients taking proper dosages, based on the Lixiana package insert, were analysed. Univariate and multivariable analyses were conducted to evaluate associations between risk factors and bleeding outcomes. Subgroup analysis was performed on high-risk patients for bleeding complications whose edoxaban dose was reduced according to the package insert. RESULTS: In total, 346 patients were included. Among them, 32 patients experienced bleeding complications. Patients with weight ≤60 kg and with cancer showed around 3.3- and 3.4-fold increased risk of bleeding complications compared to heavier patients (>60 kg) and those without cancer, respectively. In subgroup analysis with high-risk patients who took low-dose edoxaban (15 and 30 mg), weight ≤60 kg remained a significant factor for bleeding outcomes. CONCLUSION: This study showed that weight ≤60 kg and the presence of cancers could affect bleeding complications, which occurred despite proper edoxaban treatment in Asian patients. Therefore, more strict dosage guideline could be considered in populations with high proportions of Asian ethnicities.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Inhibidores del Factor Xa Tipo de estudio: Etiology_studies / Guideline / Risk_factors_studies Límite: Humans Idioma: En Revista: Br J Clin Pharmacol Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Inhibidores del Factor Xa Tipo de estudio: Etiology_studies / Guideline / Risk_factors_studies Límite: Humans Idioma: En Revista: Br J Clin Pharmacol Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido