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Correlation between polymorphism of TYMS gene and toxicity response to treatment with 5-fluoruracil and capecitabine.
Vitello, Stefano; Di Liegro, Italia; Ricciardi, Maria Rita; Verga, Chiara; Amato, Alessandra; Schiera, Gabriella; Di Liegro, Carlo; Messina, Giuseppe; Proia, Patrizia.
Afiliación
  • Vitello S; Regional Hospital S. Elia, Caltanissetta, Italy.
  • Di Liegro I; Department of Experimental Biomedicine and Clinical Neurosciences (BIONEC), University of Palermo, Palermo, Italy.
  • Ricciardi MR; Regional Hospital S. Elia, Caltanissetta, Italy.
  • Verga C; Regional Hospital S. Elia, Caltanissetta, Italy.
  • Amato A; Department of Psychological, Pedagogical and Educational Sciences, Sport and Exercise Sciences Research Unit, University of Palermo, Palermo, Italy.
  • Schiera G; Department of Biological Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy.
  • Di Liegro C; Department of Biological Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy.
  • Messina G; Department of Psychological, Pedagogical and Educational Sciences, Sport and Exercise Sciences Research Unit, University of Palermo, Palermo, Italy.
  • Proia P; Department of Psychological, Pedagogical and Educational Sciences, Sport and Exercise Sciences Research Unit, University of Palermo, Palermo, Italy.
Eur J Transl Myol ; 30(3): 8970, 2020 Sep 30.
Article en En | MEDLINE | ID: mdl-33117504
Tumorigenesis is a multiphasic process in which genetic alterations guide the progressive transformation in cancer cells1. In order to evaluate the possible correlation between some gene variants and the risk of the toxicity development onset, two of the polymorphisms of the thymidylate synthase (TYMS), rs34743033 (2R/3R) and rs16430 (DEL/INS) were investigated. We enrolled in our study 47 patients from the Hospital of Sicily. Our preliminary findings suggest that there could be a linkage between the genotypes discussed and the development of the toxicity following the chemotherapy treatment. These results need to be confirmed by further studies, however this short paper offers some initial insight into the relationships between genetic background and the better outcome for patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Transl Myol Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Transl Myol Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia