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Pushing the Frontiers of Accessible Chemical Space to Unleash Design Creativity and Accelerate Drug Discovery.
Fessard, Thomas C; Goncharenko, Kristina; Lefebvre, Quentin; Salomé, Christophe.
Afiliación
  • Fessard TC; SpiroChem AG, Mattenstrasse 24, CH-4058 Basel, Switzerland;, Email: thomas.fessard@spirochem.ch.
  • Goncharenko K; SpiroChem AG, Mattenstrasse 24, CH-4058 Basel, Switzerland.
  • Lefebvre Q; SpiroChem AG, Mattenstrasse 24, CH-4058 Basel, Switzerland.
  • Salomé C; SpiroChem AG, Mattenstrasse 24, CH-4058 Basel, Switzerland.
Chimia (Aarau) ; 74(10): 803-807, 2020 Oct 28.
Article en En | MEDLINE | ID: mdl-33115564
In highly competitive research environments, the ability to access more complex structural spaces efficiently is a predictor of a company's ability to generate novel IP-protected small molecule candidates with adequate properties, hence filling their development pipelines. SpiroChem is consistently developing new synthetic methodologies and strategies to access complex molecular structure, thereby facilitating and accelerating small molecule drug discovery. Pushing the limits of what are perceived as complex molecular structures allows SpiroChem and its clients to unleash creativity and explore meaningful chemical spaces, which are under-exploited sources of novel active molecules. In this article, we explain how we differentiated ourselves in a globalized R&D environment and we provide several snapshots of how efficient methodologies can generate complex structures, rapidly.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Creatividad / Descubrimiento de Drogas Tipo de estudio: Prognostic_studies Idioma: En Revista: Chimia (Aarau) Año: 2020 Tipo del documento: Article Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Creatividad / Descubrimiento de Drogas Tipo de estudio: Prognostic_studies Idioma: En Revista: Chimia (Aarau) Año: 2020 Tipo del documento: Article Pais de publicación: Suiza