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Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass.
Ye, Yuanchao; Abu El Haija, Marwa; Morgan, Donald A; Guo, Deng; Song, Yang; Frank, Aaron; Tian, Liping; Riedl, Ruth A; Burnett, Colin M L; Gao, Zhan; Zhu, Zhiyong; Shahi, Shailesh K; Zarei, Kasra; Couvelard, Anne; Poté, Nicolas; Ribeiro-Parenti, Lara; Bado, André; Noureddine, Lama; Bellizzi, Andrew; Kievit, Paul; Mangalam, Ashutosh K; Zingman, Leonid V; Le Gall, Maude; Grobe, Justin L; Kaplan, Lee M; Clegg, Deborah; Rahmouni, Kamal; Mokadem, Mohamad.
Afiliación
  • Ye Y; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Abu El Haija M; Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
  • Morgan DA; Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Guo D; Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Song Y; College of Pharmacy, China Medical University, 77 Puhe Rd., Liaoning 110122, P.R. China.
  • Frank A; The Biomedical Research Department, Diabetes and Obesity Research Division, Cedars Sinai Medical Center, Beverly Hills, CA 90048, USA.
  • Tian L; Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, P.R. China.
  • Riedl RA; Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Burnett CML; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Gao Z; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Zhu Z; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Shahi SK; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Zarei K; Medical Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Couvelard A; INSERM U1149, Centre de Recherche sur l'Inflammation, Université de Paris, Paris 75018, France; Department of Pathology, Bichat Hospital, AP-HP, Paris 75018, France.
  • Poté N; INSERM U1149, Centre de Recherche sur l'Inflammation, Université de Paris, Paris 75018, France; Department of Pathology, Bichat Hospital, AP-HP, Paris 75018, France.
  • Ribeiro-Parenti L; INSERM U1149, Centre de Recherche sur l'Inflammation, Université de Paris, Paris 75018, France; Department of General and Digestive Surgery, Bichat Hospital, AP-HP, Paris 75018, France.
  • Bado A; INSERM U1149, Centre de Recherche sur l'Inflammation, Université de Paris, Paris 75018, France.
  • Noureddine L; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Bellizzi A; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Kievit P; Division of Diabetes, Obesity and Metabolism, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
  • Mangalam AK; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Immunology and Molecular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  • Zingman LV; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Fraternal Orders of Eagles Diabetes Research Center, Iowa City, IA 52242, USA; Veterans Affairs Health Care System, Iowa City, IA 52242, USA; Obesity Research & Education Initiative, Univers
  • Le Gall M; INSERM U1149, Centre de Recherche sur l'Inflammation, Université de Paris, Paris 75018, France.
  • Grobe JL; Departments of Physiology and Biomedical Engineering, Medical College of Wisconsin, Milwaukee, MI 53226, USA.
  • Kaplan LM; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Obesity, Metabolism, and Nutrition Institute, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Clegg D; College of Nursing and Health Professions, Drexel University, 1601 Cherry Street, Philadelphia, PA 19102, USA.
  • Rahmouni K; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Medical Scientist Training Program, University of Iowa Carver College of Med
  • Mokadem M; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Fraternal Orders of Eagles Diabetes Research Center, Iowa City, IA 52242, US
Cell Rep ; 33(4): 108270, 2020 10 27.
Article en En | MEDLINE | ID: mdl-33113371
The exact mechanisms underlying the metabolic effects of bariatric surgery remain unclear. Here, we demonstrate, using a combination of direct and indirect calorimetry, an increase in total resting metabolic rate (RMR) and specifically anaerobic RMR after Roux-en-Y gastric bypass (RYGB), but not sleeve gastrectomy (SG). We also show an RYGB-specific increase in splanchnic sympathetic nerve activity and "browning" of visceral mesenteric fat. Consequently, selective splanchnic denervation abolishes all beneficial metabolic outcomes of gastric bypass that involve changes in the endocannabinoid signaling within the small intestine. Furthermore, we demonstrate that administration of rimonabant, an endocannabinoid receptor-1 (CB1) inverse agonist, to obese mice mimics RYGB-specific effects on energy balance and splanchnic nerve activity. On the other hand, arachidonoylethanolamide (AEA), a CB1 agonist, attenuates the weight loss and metabolic signature of this procedure. These findings identify CB1 as a key player in energy regulation post-RYGB via a pathway involving the sympathetic nervous system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Simpático / Derivación Gástrica / Endocannabinoides Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Rep Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Simpático / Derivación Gástrica / Endocannabinoides Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Rep Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos