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Variant in BCAR4 gene correlated with the breast cancer susceptibility and mRNA expression of lncRNA BCAR4 in Chinese Han population.
Peng, Rui; Cao, Jingjing; Guo, Qiaoyun; Sun, Qiuyu; Xu, Linping; Xie, Xiaojuan; Song, Chunhua.
Afiliación
  • Peng R; Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
  • Cao J; Department of Teaching and Research, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, People's Republic of China.
  • Guo Q; Department of Preventive Medicine, Heze Medical College, Heze, 274000, Shandong, People's Republic of China.
  • Sun Q; Department for Endemic Disease Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou, 450016, Henan, People's Republic of China.
  • Xu L; Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
  • Xie X; Henan Key Laboratory of Tumor Epidemiology, Zhengzhou, 450052, Henan, People's Republic of China.
  • Song C; Department of Teaching and Research, Henan Tumor Hospital, Zhengzhou, 450008, Henan, People's Republic of China.
Breast Cancer ; 28(2): 424-433, 2021 Mar.
Article en En | MEDLINE | ID: mdl-33113070
BACKGROUND: Long non-coding RNA (LncRNA) Breast cancer anti-estrogen resistance 4 (BCAR4) has been shown to participate in the biological progress of various cancers including breast cancer. Genetic Polymorphisms in BCAR4 may have an influence on the progress of breast cancer, but it is rarely studied. METHODS: In our epidemiology study, three tagging SNPs (rs4561483, rs11649623 and rs13334967) in lncRNA BCAR4 were selected for genotyping among 487 breast cancer cases and 489 healthy controls. And quantitative real-time PCR (qRT-PCR) was performed to evaluate the relative mRNA expression of BCAR4 in different genotypes of the significant locus rs13334967. RESULTS: We found that BCAR4 rs13334967 is associated with lower breast cancer risk both in codominant model (AT vs AA, OR 0.632, 95% CI 0.429-0.931, TT vs AA, OR 0.731, 95% CI 0.511-0.990) and dominant model (AT + TT vs AA, OR 0.798, 95% CI 0.571-0.970). The further results of qRT-PCR displayed that carriers with rs13334967 AT, TT genotype have lower BCAR4 mRNA expression compared with AA genotype. CONCLUSION: The research study implied that BCAR4 rs13334967 was correlated with the susceptibility to breast cancer and may impact the mRNA expression of BCAR4. LncRNA BCAR4 may be a potential biomarker and therapeutic target for breast cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / ARN Mensajero / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / ARN Largo no Codificante Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Breast Cancer Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article Pais de publicación: Japón
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / ARN Mensajero / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / ARN Largo no Codificante Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Breast Cancer Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article Pais de publicación: Japón