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Safety and efficacy of photobiomodulation therapy in oncology: A systematic review.
Bensadoun, René-Jean; Epstein, Joel B; Nair, Raj G; Barasch, Andrei; Raber-Durlacher, Judith E; Migliorati, Cesar; Genot-Klastersky, Marie-Thérèse; Treister, Nathaniel; Arany, Praveen; Lodewijckx, Joy; Robijns, Jolien.
Afiliación
  • Bensadoun RJ; Centre de Haute Energie, Nice, France.
  • Epstein JB; City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
  • Nair RG; Cedars-Sinai Health System, Los Angeles, CA, USA.
  • Barasch A; Oral Medicine/Oral Oncology, Griffith University and Haematology and Oncology, Gold Coast University Hospital, Queensland Health, Gold Coast, QLD, Australia.
  • Raber-Durlacher JE; Harvard School of Dental Medicine, Cambridge Health Alliance, Cambridge, MA, USA.
  • Migliorati C; Department of Oral Medicine, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Genot-Klastersky MT; Department of Oral and Maxillofacial Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
  • Treister N; College of Dentistry, Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida, Gainesville, FL, USA.
  • Arany P; Institut Jules-Bordet, Brussels, Belgium.
  • Lodewijckx J; Department of Oral Medicine, Harvard School of Dental Medicine, Boston, MA, USA.
  • Robijns J; School of Dental Medicine, University of Buffalo, Buffalo, NY, USA.
Cancer Med ; 9(22): 8279-8300, 2020 11.
Article en En | MEDLINE | ID: mdl-33107198
We performed a systematic review of the current literature addressing the safety and efficacy of photobiomodulation therapy (PBMT) in cancer patients. In this systematic review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. In vitro, in vivo, and clinical studies, which investigated the effect of PBMT on cell proliferation/differentiation, tumor growth, recurrence rate, and/or overall survival were included. The Medline/PubMed, EMBASE, and Scopus databases were searched through April 2020. A total of 67 studies met the inclusion criteria with 43 in vitro, 15 in vivo, and 9 clinical studies identified. In vitro studies investigating the effect of PBMT on a diverse range of cancer cell lines demonstrated conflicting results. This could be due to the differences in used parameters and the frequency of PBM applications. In vivo studies and clinical trials with a follow-up period demonstrated that PBMT is safe with regards to tumor growth and patient advantage in the prevention and treatment of specific cancer therapy-related complications. Current human studies, supported by most animal studies, show safety with PBMT using currently recommended clinical parameters, including in Head & Neck cancer (HNC) in the area of PBMT exposure. A significant and growing literature indicates that PBMT is safe and effective, and may even offer a benefit in patient overall survival. Nevertheless, continuing research is indicated to improve understanding and provide further elucidation of remaining questions regarding PBM use in oncology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia por Luz de Baja Intensidad / Neoplasias Tipo de estudio: Guideline / Prognostic_studies / Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Cancer Med Año: 2020 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia por Luz de Baja Intensidad / Neoplasias Tipo de estudio: Guideline / Prognostic_studies / Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Cancer Med Año: 2020 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos