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COVID-19 in Parkinson's disease: what holds the key?
Sainz-Amo, R; Baena-Álvarez, B; Pareés, I; Sánchez-Díez, G; Pérez-Torre, P; López-Sendón, J L; Fanjul-Arbos, S; Monreal, E; Corral-Corral, I; García-Barragán, N; Martínez-Castrillo, J C; Fasano, A; Alonso-Cánovas, A.
Afiliación
  • Sainz-Amo R; Movement Disorders Unit. Neurology Department. Hospital, Universitario Ramón y Cajal, Carretera de Colmenar km 9.100, Madrid, 28034, Spain. raquelsainzamo@gmail.com.
  • Baena-Álvarez B; Movement Disorders Unit. Neurology Department. Hospital, Universitario Ramón y Cajal, Carretera de Colmenar km 9.100, Madrid, 28034, Spain.
  • Pareés I; Movement Disorders Unit. Neurology Department. Hospital, Universitario Ramón y Cajal, Carretera de Colmenar km 9.100, Madrid, 28034, Spain.
  • Sánchez-Díez G; Movement Disorders Unit. Neurology Department. Hospital, Universitario Ramón y Cajal, Carretera de Colmenar km 9.100, Madrid, 28034, Spain.
  • Pérez-Torre P; Movement Disorders Unit. Neurology Department. Hospital, Universitario Ramón y Cajal, Carretera de Colmenar km 9.100, Madrid, 28034, Spain.
  • López-Sendón JL; Movement Disorders Unit. Neurology Department. Hospital, Universitario Ramón y Cajal, Carretera de Colmenar km 9.100, Madrid, 28034, Spain.
  • Fanjul-Arbos S; Movement Disorders Unit. Neurology Department. Hospital, Universitario Ramón y Cajal, Carretera de Colmenar km 9.100, Madrid, 28034, Spain.
  • Monreal E; Movement Disorders Unit. Neurology Department. Hospital, Universitario Ramón y Cajal, Carretera de Colmenar km 9.100, Madrid, 28034, Spain.
  • Corral-Corral I; Movement Disorders Unit. Neurology Department. Hospital, Universitario Ramón y Cajal, Carretera de Colmenar km 9.100, Madrid, 28034, Spain.
  • García-Barragán N; Movement Disorders Unit. Neurology Department. Hospital, Universitario Ramón y Cajal, Carretera de Colmenar km 9.100, Madrid, 28034, Spain.
  • Martínez-Castrillo JC; Movement Disorders Unit. Neurology Department. Hospital, Universitario Ramón y Cajal, Carretera de Colmenar km 9.100, Madrid, 28034, Spain.
  • Fasano A; Division of Neurology, Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, UHN, University of Toronto, Toronto, Canada.
  • Alonso-Cánovas A; Krembil Brain Institute, Toronto, Ontario, Canada.
J Neurol ; 268(8): 2666-2670, 2021 Aug.
Article en En | MEDLINE | ID: mdl-33098468
INTRODUCTION: Parkinson's disease (PD) is more frequent in the elderly and increases the risk of respiratory infections. Previous data on PD and SARS-CoV-2 are scarce, suggesting a poor prognosis in advanced disease and second-line therapies. METHODS: A retrospective case-control study comparing patients with PD and COVID-19 and patients with PD without COVID-19 was conducted during the pandemic period in Spain (March 1st-July 31st 2020) in a tertiary university hospital. RESULTS: Thirty-nine (COVID-19 +) and 172 (COVID-19-) PD patients were included. Fifty-nine percent were males in both groups, with similar age (75.9 ± 9.0 COVID-19 + , 73.9 ± 10.0 COVID-19-), disease duration (8.9 ± 6.2 COVID-19 + , 8.5 ± 5.6 COVID-19-) and PD treatments. COVID-19 was mild in 10 (26%), required admission in 21 (54%) and caused death in 8 (21%) patients. Dementia was the only comorbidity more frequent in COVID-19 + patients (36% vs. 14%, p = 0.0013). However, in a multivariate analysis, institutionalization was the only variable associated with COVID-19 + (OR 17.0, 95% CI 5.0-60.0, p < 0.001). When considering severe COVID-19 (admission or death) vs. mild or absent COVID-19, institutionalization, neoplasm, dementia and a lower frequency of dopamine agonists were associated with severe COVID-19. In multivariate analysis, only institutionalization [OR 5.17, 95% CI 1.57-17, p = 0.004] and neoplasm [OR 8.0, 95%CI 1.27-49.8, p = 0.027] remained significantly associated. CONCLUSION: In our experience, institutionalization and oncologic comorbidity, rather than PD-related variables, increased the risk of developing COVID-19, and impacted on its severity. These findings suggest that epidemiologic factors and frailty are key factors for COVID-19 morbidity/mortality in PD. Appropriate preventive strategies should be implemented in institutionalized patients to prevent infection and improve prognosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J Neurol Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J Neurol Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania