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Acute physical exercise increases PI3K-p110α protein content in the hypothalamus of obese mice.
Gaspar, Rafael C; Nakandakari, Susana C B R; Muñoz, Vitor R; Vieira, Renan F L; da Silva, Adelino S R; Cintra, Dennys E; de Moura, Leandro P; Ropelle, Eduardo R; Pauli, José Rodrigo.
Afiliación
  • Gaspar RC; Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil.
  • Nakandakari SCBR; Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.
  • Muñoz VR; Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil.
  • Vieira RFL; Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil.
  • da Silva ASR; Post-graduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, Brazil.
  • Cintra DE; Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.
  • de Moura LP; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, Brazil.
  • Ropelle ER; Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil.
  • Pauli JR; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, Brazil.
J Anat ; 238(3): 743-750, 2021 03.
Article en En | MEDLINE | ID: mdl-33094520
The anatomy of the hypothalamus includes many nuclei and a complex network of neurocircuits. In this context, some hypothalamic nuclei reside closer to the blood-brain barrier, allowing communication with the peripheral organs through some molecules, such as leptin. Leptin is considered the main adipokine for energy homeostasis control. Furthermore, leptin signalling in the hypothalamus can communicate with insulin signalling through the activation of phosphoinositide 3-kinase (PI3k). Previous data suggest that isoforms of PI3k are necessary to mediate insulin action in the hypothalamus. However, obese animals show impairment in the central signalling of these hormones. Thus, in the current study, we evaluated the role of acute exercise in the leptin and insulin pathways in the hypothalamus, as well as in food intake control in obese mice. Although acute physical exercise was not able to modulate leptin signalling, this protocol suppressed the increase in the suppressor of cytokine signalling 3 (SOCS3) protein levels. In addition, acute exercise increased the content of PI3k-p110α protein in the hypothalamus. The exercised animals showed a strong tendency to reduction in cumulative food intake. For the first time, our results indicate physical exercise can increase PI3k-p110α protein content in the hypothalamus of obese mice and regulate food intake.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Leptina / Fosfatidilinositol 3-Quinasa Clase I / Hipotálamo / Obesidad Límite: Animals Idioma: En Revista: J Anat Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Leptina / Fosfatidilinositol 3-Quinasa Clase I / Hipotálamo / Obesidad Límite: Animals Idioma: En Revista: J Anat Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido