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Blood adipocytokine concentration in patients with peripheral artery disease.
Spychalska-Zwolinska, Marta; Anaszewicz, Marzena; Wisniewska, Joanna; Mieczkowski, Artur; Kowalczyk, Gabriel; Banas, Wioletta; Czerniak, Beata; Suppan, Karol; Lis, Kinga; Zbikowska-Gotz, Magdalena; Bartuzi, Zbigniew; Budzynski, Jacek.
Afiliación
  • Spychalska-Zwolinska M; Department of Vascular and Internal Diseases, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
  • Anaszewicz M; Department of Vascular and Internal Diseases, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
  • Wisniewska J; Department of Vascular and Internal Diseases, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
  • Mieczkowski A; Department of Vascular and Internal Diseases, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
  • Kowalczyk G; Department of Vascular and Internal Diseases, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
  • Banas W; Department of Vascular and Internal Diseases, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
  • Czerniak B; Department of Vascular and Internal Diseases, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
  • Suppan K; Department of Vascular and Internal Diseases, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
  • Lis K; Department of Allergology, Clinical Immunology and Internal Diseases, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
  • Zbikowska-Gotz M; Department of Allergology, Clinical Immunology and Internal Diseases, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
  • Bartuzi Z; Department of Allergology, Clinical Immunology and Internal Diseases, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
  • Budzynski J; Department of Vascular and Internal Diseases, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland - budz@cps.pl.
Int Angiol ; 39(6): 500-508, 2020 Dec.
Article en En | MEDLINE | ID: mdl-33086778
BACKGROUND: Inflammatory responses mediated by adipocytokines may affect both atherosclerosis development and progression, as well as the risk of in-stent restenosis. The aim of this study was to determine the relationships between blood leptin, adiponectin and tumor necrosis factor-α (TNF-α) concentrations and the 1-year outcome of superficial femoral artery (SFA) stenting. METHODS: Blood concentrations of leptin, adiponectin and TNF-α were determined in 70 patients undergoing SFA stenting due to intermittent claudication and in 40 patients undergoing carotid artery stenting (CAS). All subjects were followed up for at least 1 year in relation to the occurrence of clinically driven target lesion revascularization (TLR) or a major adverse cardiovascular event (MACE). RESULTS: Patients undergoing SFA stenting and CAS had similar blood adipocytokine concentrations. Patients with diabetes mellitus presented a higher leptin concentration, lower adiponectin-to-leptin ratio, and lower blood adiponectin concentration indexed to fat mass (FM) and to visceral adiposity score (VAS). In Kaplan-Meier analysis, blood concentration of TNF-α indexed to FM and to VAS was higher in patients who underwent TLR and MACE. However, in multifactorial analysis, the severity of atherosclerosis lesions in the femoropopliteal vascular region, estimated in relation to TASC-II classification, was the only predictor of TLR. CONCLUSIONS: Circulating adipocytokines did not distinguish patients with different clinical manifestations of atherosclerosis. Higher ratios of TNF-α -to-FM and to VAS before SFA stenting were related to TLR and MACE occurrence. Dysregulation in adipocytokine secretion may be a potential mediator of a proatherogenic action of diabetes mellitus in patients with peripheral artery disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angioplastia de Balón / Enfermedad Arterial Periférica Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Int Angiol Año: 2020 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angioplastia de Balón / Enfermedad Arterial Periférica Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Int Angiol Año: 2020 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Italia