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Quality of Life in Patients with Neuroendocrine Neoplasms: The Role of Severity, Clinical Heterogeneity, and Resilience.
Scandurra, Cristiano; Modica, Roberta; Maldonato, Nelson Mauro; Dolce, Pasquale; Dipietrangelo, Greta G; Centello, Roberta; Di Vito, Valentina; Bottiglieri, Filomena; de Cicco, Federica; Giannetta, Elisa; Isidori, Andrea M; Lenzi, Andrea; Muzii, Benedetta; Faggiano, Antongiulio; Colao, Annamaria.
Afiliación
  • Scandurra C; Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
  • Modica R; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
  • Maldonato NM; Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
  • Dolce P; Department of Public Health, University of Naples Federico II, Naples, Italy.
  • Dipietrangelo GG; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Centello R; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Di Vito V; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Bottiglieri F; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
  • de Cicco F; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
  • Giannetta E; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Isidori AM; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Lenzi A; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Muzii B; Department of Humanistic Studies, University of Naples Federico II, Naples, Italy.
  • Faggiano A; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Colao A; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
J Clin Endocrinol Metab ; 106(1): e316-e327, 2021 01 01.
Article en En | MEDLINE | ID: mdl-33084861
CONTEXT: Although health-related quality of life (HRQoL) is a fundamental outcome in oncological clinical trials, its evaluation in the neuroendocrine neoplasm (NEN) research field is still limited. OBJECTIVES: This study assessed the role of clinical severity (ie, presence or absence of metastasis and lines of therapies) and heterogeneity (ie, primary site, types of therapy, biology, and surgery) of NEN in relation to HRQoL, as well as resilience as a moderator between clinical severity and HRQoL. DESIGN: Cross-sectional multicentric study. SETTING: Italian university hospitals. PATIENTS: A total of 99 Italian patients (53 men and 46 women) with NEN and ranged in age from 22-79 years old. MAIN OUTCOME MEASURE: Severity and heterogeneity of NENs, HRQoL, and resilience. RESULTS: The presence of metastasis and a greater number of therapies affected the global health and some physical symptoms. Resilience was associated with global health, functional status, and some physical symptoms, and it moderated the impact of metastases on constipation and of the multiple therapies on diarrhea and financial problems. Patients with NEN in districts other than the gastroenteropancreatic system and those in follow-up perceived fewer physical symptoms than their counterparts. Patients with a sporadic NEN perceived their functional status, global health, and disease-related worries as better than those with a hereditary NEN. Patients who underwent surgery were lower in constipation than their counterparts. CONCLUSION: These findings highlight the need to assess the relationships between the clinical severity and heterogeneity of NEN with HRQoL and the role of resilience in improving patients' HRQoL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Tumores Neuroendocrinos / Resiliencia Psicológica Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Clin Endocrinol Metab Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Tumores Neuroendocrinos / Resiliencia Psicológica Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Clin Endocrinol Metab Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos