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Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders, Diffuse Large B-Cell Lymphoma Type, in a Patient with Behçet's Disease Treated with Cyclosporine A.
Urano, Yuka; Ohe, Rintaro; Yamada, Akane; Kabasawa, Takanobu; Suzuki, Kazushi; Kitaoka, Takumi; Tamazawa, Nobuyuki; Aung, Naing Ye; Utsunomiya, Aya; Toubai, Tomomi; Ishizawa, Kenichi.
Afiliación
  • Urano Y; Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
  • Ohe R; Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
  • Yamada A; Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan.
  • Kabasawa T; Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
  • Suzuki K; Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
  • Kitaoka T; Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
  • Tamazawa N; Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
  • Aung NY; Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
  • Utsunomiya A; Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.
  • Toubai T; Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan.
  • Ishizawa K; Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan.
Case Rep Oncol ; 13(3): 1145-1151, 2020.
Article en En | MEDLINE | ID: mdl-33082762
A 40-year-old man had been treated for Behçet's disease (BD) with cyclosporine A (CsA) for 14 years. He presented multiple lymphadenopathies with fever. Histological examination of surgical biopsy showed other iatrogenic immunodeficiency-associated lymphoproliferative disorders, diffuse large B-cell lymphoma type with positivity for Epstein-Barr virus encoding RNA-1 (EBER-1). BCL2-IgH, BCL6-IgH, and MYC-IgH translocations were not detected. CsA was stopped, and R-CHOP therapy was initiated. However, his lymphoma was chemotherapy resistant and rapidly progressed. To the best of our knowledge, this is the first case of diffuse large B-cell lymphoma that occurred in a BD patient treated with CsA reported in English. Both BD and CsA are associated with the pathogenesis of lymphoma. We also describe extremely rare cases in the form of a literature review.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Case Rep Oncol Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Case Rep Oncol Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza