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Adolescent Nonalcoholic Fatty Liver Disease and Type 2 Diabetes in Young Adulthood.
Bardugo, Aya; Bendor, Cole D; Zucker, Inbar; Lutski, Miri; Cukierman-Yaffe, Tali; Derazne, Estela; Mosenzon, Ofri; Tzur, Dorit; Beer, Zivan; Pinhas-Hamiel, Orit; Ben-Ami, Michal; Fishman, Boris; Ben-Ami Shor, Dana; Raz, Itamar; Afek, Arnon; Gerstein, Hertzel C; Häring, Hans-Ulrich; Tirosh, Amir; Levi, Zohar; Twig, Gilad.
Afiliación
  • Bardugo A; Department of Military Medicine, Hebrew University, Jerusalem and the Israel Defense Forces Medical Corps, Ramat Gan, Israel.
  • Bendor CD; Department of Military Medicine, Hebrew University, Jerusalem and the Israel Defense Forces Medical Corps, Ramat Gan, Israel.
  • Zucker I; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Lutski M; The Israel Center for Disease Control, Ministry of Health, Ramat Gan, Israel.
  • Cukierman-Yaffe T; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Derazne E; The Israel Center for Disease Control, Ministry of Health, Ramat Gan, Israel.
  • Mosenzon O; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Tzur D; Institute of Endocrinology, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
  • Beer Z; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Pinhas-Hamiel O; The Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel.
  • Ben-Ami M; Department of Military Medicine, Hebrew University, Jerusalem and the Israel Defense Forces Medical Corps, Ramat Gan, Israel.
  • Fishman B; Department of Military Medicine, Hebrew University, Jerusalem and the Israel Defense Forces Medical Corps, Ramat Gan, Israel.
  • Ben-Ami Shor D; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Raz I; Pediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
  • Afek A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Gerstein HC; Pediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
  • Häring HU; Department of Military Medicine, Hebrew University, Jerusalem and the Israel Defense Forces Medical Corps, Ramat Gan, Israel.
  • Tirosh A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Levi Z; Internal Medicine D and Hypertension Unit, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
  • Twig G; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
J Clin Endocrinol Metab ; 106(1): e34-e44, 2021 01 01.
Article en En | MEDLINE | ID: mdl-33075820
CONTEXT: The long-term risk of type 2 diabetes in adolescents with nonalcoholic fatty liver disease (NAFLD) is unclear. OBJECTIVE: To assess type 2 diabetes risk among adolescents with NAFLD. DESIGN AND SETTING: A nationwide, population-based study of Israeli adolescents who were examined before military service during 1997-2011 and were followed until December 31, 2016. PARTICIPANTS: A total of 1 025 796 normoglycemic adolescents were included. INTERVENTIONS: Biopsy or radiographic tests were prerequisite for NAFLD diagnosis. Data were linked to the Israeli National Diabetes Registry. MAIN OUTCOME MEASURES: Type 2 diabetes incidence. RESULTS: During a mean follow-up of 13.3 years, 12 of 633 adolescents with NAFLD (1.9%; all with high body mass index [BMI] at baseline) were diagnosed with type 2 diabetes compared with 2917 (0.3%) adolescents without NAFLD. The hazard ratio (HR) for type 2 diabetes was 2.59 (95% confidence interval [CI], 1.47-4.58) for the NAFLD vs. the non-NAFLD group after adjustment for BMI and sociodemographic confounders. The elevated risk persisted in several sensitivity analyses. These included an analysis of persons without other metabolic comorbidities (adjusted HR, 2.75 [95% CI, 1.48-5.14]) and of persons with high BMI; and an analysis whose outcome was type 2 diabetes by age 30 years (adjusted HR, 2.14 [95% CI, 1.02-4.52]). The results remained significant when a sex-, birth year-, and BMI-matched control group was the reference (adjusted HR, 2.98 [95% CI, 1.54-5.74]). CONCLUSIONS: Among normoglycemic adolescents, NAFLD was associated with an increased adjusted risk for type 2 diabetes, which may be apparent before age 30 years.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: J Clin Endocrinol Metab Año: 2021 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: J Clin Endocrinol Metab Año: 2021 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos