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Dynamic Positron Emission Tomography/Computed Tomography Imaging Correlate of Nonalcoholic Steatohepatitis.
Sarkar, Souvik; Matsukuma, Karen E; Spencer, Benjamin; Chen, Shuai; Olson, Kristin A; Badawi, Ramsey D; Corwin, Michael T; Wang, Guobao.
Afiliación
  • Sarkar S; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of California, Davis, Sacramento, California. Electronic address: ssarkar@ucdavis.edu.
  • Matsukuma KE; Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California.
  • Spencer B; Department of Radiology, University of California, Davis, Sacramento, California.
  • Chen S; Division of Biostatistics, Department of Public Health Sciences, University of California, Davis, Sacramento, California.
  • Olson KA; Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California.
  • Badawi RD; Department of Radiology, University of California, Davis, Sacramento, California.
  • Corwin MT; Department of Radiology, University of California, Davis, Sacramento, California.
  • Wang G; Department of Radiology, University of California, Davis, Sacramento, California. Electronic address: gbwang@ucdavis.edu.
Clin Gastroenterol Hepatol ; 19(11): 2441-2443, 2021 11.
Article en En | MEDLINE | ID: mdl-33075553
Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease characterized by lobular inflammation and hepatocyte injury and is a key determinant of clinical outcome.1 Liver biopsy remains the gold standard for diagnosis but is limited by risks of the procedure and interobserver variability. Although magnetic resonance imaging (MRI)-based technology may provide novel means to identify NASH,2 there remains a significant need for other modalities to diagnose NASH noninvasively. Glucose transport, an integral tissue process altered in NASH,3 is measurable with 18F-fluorodeoxyglucose positron emission tomography (FDG PET). Because unenhanced computed tomography (CT) scan can detect hepatic steatosis quite reliably,4 and PET combines unenhanced CT for attenuation correction, we hypothesized that measurement of the combination of glucose transport by PET and steatosis by CT could yield a reliable radiologic correlate of NASH.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Hígado Graso no Alcohólico Límite: Humans Idioma: En Revista: Clin Gastroenterol Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Hígado Graso no Alcohólico Límite: Humans Idioma: En Revista: Clin Gastroenterol Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos