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Effects of nafamostat mesilate on 5-hydroxytryptamine release from isolated ileal tissues induced by anti-cancer drugs in rats.
Kikuchi, Kaoru; Hamaue, Naoya; Machida, Takuji; Iizuka, Kenji; Minami, Masaru; Hirafuji, Masahiko.
Afiliación
  • Kikuchi K; Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido.
  • Hamaue N; Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido.
  • Machida T; Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido.
  • Iizuka K; Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido.
  • Minami M; Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido.
  • Hirafuji M; Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido.
Biomed Res ; 41(5): 253-257, 2020.
Article en En | MEDLINE | ID: mdl-33071261
Administration of cisplatin and methotrexate significantly increased 5-hydroxytryptamine (5-HT) release from intestinal tissues isolated at 72 h after administration in rats. Daily administration with nafamostat mesilate, a potent serine protease inhibitor, significantly inhibited the release of 5-HT induced by methotrexate, but not by cisplatin, in a dose-dependent manner. When applied to isolated ileal tissues in vitro, nafamostat mesilate also significantly inhibited the release of 5-HT induced by methotrexate, but not by cisplatin, in a concentration-dependent manner. These results suggest that serine proteases are involved in the mechanism of the methotrexate-induced release of 5-HT from the rat small intestine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzamidinas / Serotonina / Guanidinas / Íleon Límite: Animals Idioma: En Revista: Biomed Res Año: 2020 Tipo del documento: Article Pais de publicación: Japón
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzamidinas / Serotonina / Guanidinas / Íleon Límite: Animals Idioma: En Revista: Biomed Res Año: 2020 Tipo del documento: Article Pais de publicación: Japón