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Carcinoid Heart Disease: Pathophysiology, Pathology, Clinical Manifestations, and Management.
Jin, Chengyue; Sharma, Ajay Nair; Thevakumar, Balasingam; Majid, Muhammad; Al Chalaby, Shahad; Takahashi, Nene; Tanious, Ashraf; Arockiam, Aro Daniela; Beri, Neil; Amsterdam, Ezra A.
Afiliación
  • Jin C; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California (Davis) Medical Center, Sacramento, California, USA.
  • Sharma AN; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California (Davis) Medical Center, Sacramento, California, USA.
  • Thevakumar B; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California (Davis) Medical Center, Sacramento, California, USA.
  • Majid M; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California (Davis) Medical Center, Sacramento, California, USA.
  • Al Chalaby S; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California (Davis) Medical Center, Sacramento, California, USA.
  • Takahashi N; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California (Davis) Medical Center, Sacramento, California, USA.
  • Tanious A; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California (Davis) Medical Center, Sacramento, California, USA.
  • Arockiam AD; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California (Davis) Medical Center, Sacramento, California, USA.
  • Beri N; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California (Davis) Medical Center, Sacramento, California, USA.
  • Amsterdam EA; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California (Davis) Medical Center, Sacramento, California, USA, eaamsterdam@ucdavis.edu.
Cardiology ; 146(1): 65-73, 2021.
Article en En | MEDLINE | ID: mdl-33070143
Carcinoid heart disease (CHD) is a rare and potentially lethal manifestation of an advanced carcinoid (neuroendocrine) tumor. The pathophysiology of CHD is related to vasoactive substances secreted by the tumor, of which serotonin is most prominent in the pathophysiology of CHD. Serotonin stimulates fibroblast growth and fibrogenesis, which can lead to cardiac valvular fibrosis. CHD primarily affects right heart valves, causing tricuspid and pulmonic regurgitation and less frequently stenosis of these valves. Left heart valves are usually spared because vasoactive substances such as serotonin are enzymatically inactivated in the lung vasculature. The pathology of CHD is characterized by plaque-like deposition of fibrous tissue on valvular cusps, leaflets, papillary muscles, chordae, and ventricular walls. Symptomatic CHD usually presents between 50 and 70 years of age, initially as dyspnea and fatigue. Echocardiography is the mainstay of imaging and demonstrates thickened right heart valves with limited mobility and regurgitation. Treatment focuses on control of the underlying carcinoid syndrome, targeting subsequent valvular heart disease and managing consequent heart failure. Surgical valve replacement and catheter-directed valve procedures may be effective for selected patients with CHD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Patología Clínica / Insuficiencia de la Válvula Pulmonar / Cardiopatía Carcinoide / Enfermedades de las Válvulas Cardíacas Límite: Humans Idioma: En Revista: Cardiology Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Patología Clínica / Insuficiencia de la Válvula Pulmonar / Cardiopatía Carcinoide / Enfermedades de las Válvulas Cardíacas Límite: Humans Idioma: En Revista: Cardiology Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza