Inclusion Complex of Docetaxel with Sulfobutyl Ether ß-Cyclodextrin: Preparation, In Vitro Cytotoxicity and In Vivo Safety.
Polymers (Basel)
; 12(10)2020 Oct 13.
Article
en En
| MEDLINE
| ID: mdl-33066097
Docetaxel (DTX), as a first-line anti-tumor drug, has been studied for decades for its diverse bioactivities. However, DTX presents poor solubility in water, low bioavailability and serious toxic side effects which has hindered its application in the clinic. To address these problems, docetaxel-sulfobutyl ether-ß-cyclodextrin inclusion complex (DTX-SBE-ß-CD) was prepared successfully by saturated aqueous solution method. Sulfobutyl ether ß-cyclodetrin (SBE-ß-CD) is used as delivery material. For this study, the inclusion complex of docetaxel with sulfobutyl ether ß-cyclodetrin (DTX-SBE-ß-CD) was prepared and optimized its properties to enhance the cytotoxicity of cancer cells. A large number of physical characterization results showed that DTX-SBE-ß-CD inclusion complex was successfully prepared by saturated aqueous solution method. DTX-SBE-ß-CD inclusion complex was optimized by Central Composite Design. DTX-SBE-ß-CD had an inhibitory effect on the in vitro determination of MCF-7 and HepG2 cells by MTT assay. Pharmacokinetic studies were carried out on male Sprague-Dawley rats by tail injection, including the distribution, metabolism and elimination of DTX-SBE-ß-CD in vivo. In the experimental study of inhibition of cancer cells, DTX and DTX-SBE-ß-CD showed apparent concentration-dependent inhibitory actions on tumor cells and the inhibition of DTX-SBE-ß-CD group was more obvious.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Polymers (Basel)
Año:
2020
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Suiza