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7-T MRI of explanted liver and ex-vivo pancreatic specimens: prospective study protocol of radiological-pathological correlation feasibility (the EXLIPSE project).
Cervelli, Rosa; Cencini, Matteo; Buonincontri, Guido; Campana, Francesco; Cacciato Insilla, Andrea; Aringhieri, Giacomo; De Simone, Paolo; Boggi, Ugo; Campani, Daniela; Tosetti, Michela; Crocetti, Laura.
Afiliación
  • Cervelli R; Division of Diagnostic and Interventional Radiology, University of Pisa, Via Paradisa, 2 - Cisanello Hospital, 56100, Pisa, Italy.
  • Cencini M; IMAGO7 Foundation - IRCCS Stella Maris, Pisa, Italy.
  • Buonincontri G; IMAGO7 Foundation - IRCCS Stella Maris, Pisa, Italy.
  • Campana F; Division of Diagnostic and Interventional Radiology, University of Pisa, Via Paradisa, 2 - Cisanello Hospital, 56100, Pisa, Italy.
  • Cacciato Insilla A; Division of Pathology, University of Pisa, Pisa, Italy.
  • Aringhieri G; Division of Diagnostic and Interventional Radiology, University of Pisa, Via Paradisa, 2 - Cisanello Hospital, 56100, Pisa, Italy.
  • De Simone P; Division of Hepatic Surgery and Liver Transplant, University of Pisa, Pisa, Italy.
  • Boggi U; Division of General and Transplant and Surgery, University of Pisa, Pisa, Italy.
  • Campani D; Division of Pathology, University of Pisa, Pisa, Italy.
  • Tosetti M; IMAGO7 Foundation - IRCCS Stella Maris, Pisa, Italy.
  • Crocetti L; Division of Diagnostic and Interventional Radiology, University of Pisa, Via Paradisa, 2 - Cisanello Hospital, 56100, Pisa, Italy. laura.crocetti@med.unipi.it.
Eur Radiol Exp ; 4(1): 58, 2020 10 15.
Article en En | MEDLINE | ID: mdl-33057851
The study focuses on radiological-pathological correlation between imaging of ex vivo samples obtained by a 7-T scanner and histological examination. The specimens will be derived from native explanted cirrhotic livers, liver grafts excluded from donation because of severe steatosis, and primary pancreatic tumours. Magnetic resonance imaging (MRI) examinations will be performed within 24 h from liver or pancreatic lesion surgical removal. The MRI protocol will include morphological sequences, quantitative T1, T2, and fat-, water-fraction maps with Cartesian k-space acquisition, and multiparametric methods based on a transient-state "MRI fingerprinting". Finally, the specimen will be fixed by formalin. Qualitative imaging analysis will be performed by two independent blinded radiologists to assess image consistency score. Quantitative analysis will be performed by drawing regions of interest on different tissue zones to measure T1 and T2 relaxation times as well as fat- and water-fraction. The same tissue areas will be analysed by the pathologists. This study will provide the possibility to improve our knowledge about qualitative and quantitative abdominal imaging assessment at 7 T, by correlating imaging characteristics and the corresponding histological composition of ex vivo specimens, in order to identify imaging biomarkers. Trial registration: ClinicalTrials.gov : 13646. Registered 9 July 2019-retrospectively registered.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Proyectos de Investigación / Imagen por Resonancia Magnética / Hígado Graso Tipo de estudio: Guideline / Observational_studies / Prognostic_studies / Qualitative_research Límite: Humans Idioma: En Revista: Eur Radiol Exp Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Proyectos de Investigación / Imagen por Resonancia Magnética / Hígado Graso Tipo de estudio: Guideline / Observational_studies / Prognostic_studies / Qualitative_research Límite: Humans Idioma: En Revista: Eur Radiol Exp Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido