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Effect of vitamin E on cisplatin-induced memory impairment in male rats.
Hosseinzadeh, Masoud; Alizadeh, Amir; Heydari, Parnian; Kafami, Marzieh; Hosseini, Mahmoud; Beheshti, Farimah; Marefati, Narges; Ghanbarabadi, Moustafa.
Afiliación
  • Hosseinzadeh M; Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.
  • Alizadeh A; Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.
  • Heydari P; Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.
  • Kafami M; Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
  • Hosseini M; Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
  • Beheshti F; Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Marefati N; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Ghanbarabadi M; Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Acta Neuropsychiatr ; 33(1): 43-48, 2021 Feb.
Article en En | MEDLINE | ID: mdl-33054896
OBJECTIVE: Neurotoxicity is an adverse effect caused by cisplatin due to inflammation and oxidative stress in the central nervous system. The present study aimed to assess the effects of vitamin E injection on the learning and memory of rats with cisplatin-induced cognitive impairment. METHODS: Male rats were administered with cisplatin (2 mg/kg/7 day; intraperitoneally [i i.p.]) and/or vitamin E (200 mg/kg/7 day; i.p.) for 1 week, and the control group received saline solution. Spatial memory was evaluated using Morris water maze (MWM). In addition, the hippocampal concentrations of malondialdehyde (MDA), thiol, and superoxide dismutase (SOD) were measured using biochemical methods. RESULTS: According to the findings, cisplatin significantly increased the escape latency, while decreasing the time spent and travelled pathway in the target quadrant on the final trial day compared to the control group. Furthermore, pre-treatment with vitamin E significantly reversed all the results in the spatial memory test. The biochemical data indicated that vitamin E could decrease MDA activity and increase thiol and SOD activity compared to the control group. CONCLUSION: According to the results, vitamin E could improve cisplatin-induced memory impairment possibly through affecting the hippocampal oxidative status.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina E / Cisplatino / Memoria Espacial / Trastornos de la Memoria Tipo de estudio: Observational_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Acta Neuropsychiatr Año: 2021 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina E / Cisplatino / Memoria Espacial / Trastornos de la Memoria Tipo de estudio: Observational_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Acta Neuropsychiatr Año: 2021 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido