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Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility.
Esfandyari, Sahar; Chugh, Rishi Man; Park, Hang-Soo; Hobeika, Elie; Ulin, Mara; Al-Hendy, Ayman.
Afiliación
  • Esfandyari S; Department of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA.
  • Chugh RM; Department of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA.
  • Park HS; Department of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA.
  • Hobeika E; Fertility Centers of Illinois, Glenview, IL 60026, USA.
  • Ulin M; Department of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA.
  • Al-Hendy A; Department of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA.
Cells ; 9(10)2020 10 08.
Article en En | MEDLINE | ID: mdl-33050021
Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and couples. Mesenchymal stem cells (MSCs) have received increasing attention as a potential cell-based therapy, with several advantages over other cell sources, including greater abundance, fewer ethical considerations, and high capacity for self-renewal and differentiation. Clinical researchers have examined the therapeutic use of MSCs in female infertility. In this review, we discuss recent studies on the use of MSCs in various reproductive disorders that lead to infertility. We also describe the role of microRNAs (miRNAs) and exosomal miRNAs in controlling MSC gene expression and driving MSC therapeutic outcomes. The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency, and to improve reproductive health for a significant number of women worldwide.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Células Madre Mesenquimatosas / Células Madre Mesenquimatosas / Infertilidad Femenina Aspecto: Ethics / Patient_preference Límite: Female / Humans Idioma: En Revista: Cells Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Células Madre Mesenquimatosas / Células Madre Mesenquimatosas / Infertilidad Femenina Aspecto: Ethics / Patient_preference Límite: Female / Humans Idioma: En Revista: Cells Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza