Nanozymes and Glucuronides: Glucuronidase, Esterase, and/or Transferase Activity.

Walther, Raoul; van den Akker, Wouter; Fruergaard, Anne Sofie; Zelikin, Alexander N

Walther, Raoul; van den Akker, Wouter; Fruergaard, Anne Sofie; Zelikin, Alexander N.

Afiliación

Walther R; Department of Chemistry, Aarhus University, Aarhus, 8000, Denmark.
van den Akker W; Department of Chemistry, Aarhus University, Aarhus, 8000, Denmark.
Fruergaard AS; Department of Chemistry, Aarhus University, Aarhus, 8000, Denmark.
Zelikin AN; Department of Chemistry, Aarhus University, Aarhus, 8000, Denmark.

Small ; 16(44): e2004280, 2020 11.

Article en En | MEDLINE | ID: mdl-33048432

RESUMEN

Nanozymes are fundamentally interesting catalysts that are investigated as alternatives to fragile protein-enzymes for applications in biotechnology, for prodrug activation, and use in biomedicine, as well as the catalysts that contributed to the Origin of Life. However, until now, nanozymes mostly have been documented to exhibit activity as red/ox catalysts, whereas examples of activity outside this broad class of reactions are very few. Herein, activity of nanozymes on glucuronide prodrugs is investigated, specifically focusing on the mechanism of prodrug conversion reactions. The main finding of this work is that nanozymes exhibit glucuronide-like activity, but also catalyze prodrug conversion via esterase-like mechanism and facilitate group transfer reactions.

Asunto(s)

Glucurónidos; Profármacos; Esterasas; Glucuronidasa; Transferasas

Palabras clave

catalysis; glucuronide; nanozymes; prodrugs

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Profármacos / Glucurónidos Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Alemania

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