Your browser doesn't support javascript.
loading
Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium.
Sajuthi, Satria P; DeFord, Peter; Li, Yingchun; Jackson, Nathan D; Montgomery, Michael T; Everman, Jamie L; Rios, Cydney L; Pruesse, Elmar; Nolin, James D; Plender, Elizabeth G; Wechsler, Michael E; Mak, Angel C Y; Eng, Celeste; Salazar, Sandra; Medina, Vivian; Wohlford, Eric M; Huntsman, Scott; Nickerson, Deborah A; Germer, Soren; Zody, Michael C; Abecasis, Gonçalo; Kang, Hyun Min; Rice, Kenneth M; Kumar, Rajesh; Oh, Sam; Rodriguez-Santana, Jose; Burchard, Esteban G; Seibold, Max A.
Afiliación
  • Sajuthi SP; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
  • DeFord P; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
  • Li Y; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
  • Jackson ND; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
  • Montgomery MT; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
  • Everman JL; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
  • Rios CL; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
  • Pruesse E; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
  • Nolin JD; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
  • Plender EG; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
  • Wechsler ME; Department of Medicine, National Jewish Health, Denver, CO, USA.
  • Mak ACY; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Eng C; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Salazar S; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Medina V; Centro de Neumología Pediátrica, San Juan, Puerto Rico.
  • Wohlford EM; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Huntsman S; Division of Pediatric Allergy and Immunology, University of California San Francisco, San Francisco, CA, USA.
  • Nickerson DA; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Germer S; Department of Genome Sciences, University of Washington, Seattle, WA, USA.
  • Zody MC; Northwest Genomics Center, Seattle, WA, USA.
  • Abecasis G; Brotman Baty Institute, Seattle, WA, USA.
  • Kang HM; New York Genome Center, New York City, NY, USA.
  • Rice KM; New York Genome Center, New York City, NY, USA.
  • Kumar R; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Oh S; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Rodriguez-Santana J; Department of Biostatistics, University of Washington, Seattle, WA, USA.
  • Burchard EG; Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Chicago, IL, USA.
  • Seibold MA; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Nat Commun ; 11(1): 5139, 2020 10 12.
Article en En | MEDLINE | ID: mdl-33046696
Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, an emerging virus that utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the factors affecting the pattern and levels of expression of these genes is important for deeper understanding of SARS-CoV-2 tropism and pathogenesis. Here we explore the role of genetics and co-expression networks in regulating these genes in the airway, through the analysis of nasal airway transcriptome data from 695 children. We identify expression quantitative trait loci for both ACE2 and TMPRSS2, that vary in frequency across world populations. We find TMPRSS2 is part of a mucus secretory network, highly upregulated by type 2 (T2) inflammation through the action of interleukin-13, and that the interferon response to respiratory viruses highly upregulates ACE2 expression. IL-13 and virus infection mediated effects on ACE2 expression were also observed at the protein level in the airway epithelium. Finally, we define airway responses to common coronavirus infections in children, finding that these infections generate host responses similar to other viral species, including upregulation of IL6 and ACE2. Our results reveal possible mechanisms influencing SARS-CoV-2 infectivity and COVID-19 clinical outcomes.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Viral / Serina Endopeptidasas / Interferones / Infecciones por Coronavirus / Peptidil-Dipeptidasa A / Interleucina-13 / Betacoronavirus / Mucosa Nasal Tipo de estudio: Prognostic_studies Límite: Child / Humans / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Viral / Serina Endopeptidasas / Interferones / Infecciones por Coronavirus / Peptidil-Dipeptidasa A / Interleucina-13 / Betacoronavirus / Mucosa Nasal Tipo de estudio: Prognostic_studies Límite: Child / Humans / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido