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Changes in quality of life, cognition and functional status following catheter ablation of atrial fibrillation.
Piccini, Jonathan P; Todd, Derick M; Massaro, Tyler; Lougee, Aimee; Haeusler, Karl Georg; Blank, Benjamin; de Bono, Joseph Paul; Callans, David J; Elvan, Arif; Fetsch, Thomas; Van Gelder, Isabelle; Gentlesk, Philip; Grimaldi, Massimo; Hansen, Jim; Hindricks, Gerhard; Al-Khalidi, Hussein; Mont, Lluis; Nielsen, Jens Cosedis; Noelker, Georg; De Potter, Tom; Scherr, Daniel; Schotten, Ulrich; Themistoclakis, Sakis; Vijgen, Johan; Di Biase, Luigi; Kirchhof, Paulus.
Afiliación
  • Piccini JP; Division of Cardiology, Duke University Medical Center & Duke Clinical Research Institute, Durham, North Carolina, USA jonathan.piccini@duke.edu.
  • Todd DM; Cardiology, Liverpool Heart and Chest Hospital, Liverpool, UK.
  • Massaro T; Biostatistics, Duke University Medical Center, Durham, North Carolina, USA.
  • Lougee A; Biostatistics, Duke Clinical Research Institute, Durham, North Carolina, USA.
  • Haeusler KG; Department of Neurology, Universitätsklinikum Würzburg, Wurzburg, Germany.
  • Blank B; Atrial Fibrillation NETwork association (AFNET), Munster, Germany.
  • de Bono JP; Atrial Fibrillation NETwork association (AFNET), Munster, Germany.
  • Callans DJ; Institute of Cardiovascular Sciences, University Hospital Birmingham, Birmingham, West Midlands, UK.
  • Elvan A; Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
  • Fetsch T; Cardiology, Isala Klinieken, Zwolle, The Netherlands.
  • Van Gelder I; Cardiology, The Clinical Research Institute, Muncher, Germany.
  • Gentlesk P; Cardiology, University Medical Centre Groningen Thorax Centre, Groningen, The Netherlands.
  • Grimaldi M; Cardiology, Sentara Norfolk General Hospital, Norfolk, Virginia, USA.
  • Hansen J; Ente Ecclesiastico Ospedale Generale Regionale Francesco Miulli, Acquaviva delle Fonti, Puglia, Italy.
  • Hindricks G; Department of Cardiology, Gentofte Hospital, Gentofte, Hovedstaden, Denmark.
  • Al-Khalidi H; Cardiology, University of Leipzig, Leipzig, Germany.
  • Mont L; Duke Clinical Research Institute, Durham, North Carolina, USA.
  • Nielsen JC; Cardiovascular Institute, University of Barcelona, Barcelona, Spain.
  • Noelker G; Cardiology B, Aarhus University Hospital, Aarhus N, Denmark.
  • De Potter T; Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany.
  • Scherr D; Cardiology, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium.
  • Schotten U; Cardiology, Medical University of Graz, Graz, Austria.
  • Themistoclakis S; Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, Limburg, Netherlands.
  • Vijgen J; Physiology, Maastricht University Medical Centre, Maastricht, The Netherlands.
  • Di Biase L; Cardiology, Ospedale Dell'Angelo, Mestre-Venice, Italy.
  • Kirchhof P; Heart Center, Jessa Hospital, Hasselt, Belgium.
Heart ; 106(24): 1919-1926, 2020 12.
Article en En | MEDLINE | ID: mdl-33046527
OBJECTIVE: To investigate changes in quality of life (QoL), cognition and functional status according to arrhythmia recurrence after atrial fibrillation (AF) ablation. METHODS: We compared QoL, cognition and functional status in patients with recurrent atrial tachycardia (AT)/AF versus those without recurrent AT/AF in the AXAFA-AFNET 5 clinical trial. We also sought to identify factors associated with improvement in QoL and functional status following AF ablation by overall change scores with and without analysis of covariance (ANCOVA). RESULTS: Among 518 patients who underwent AF ablation, 154 (29.7%) experienced recurrent AT/AF at 3 months. Patients with recurrent AT/AF had higher mean CHA2DS2-VASc scores (2.8 vs 2.3, p<0.001) and more persistent forms of AF (51 vs 39%, p=0.012). Median changes in the SF-12 physical (3 (25th, 75th: -1, 8) vs 1 (-5, 8), p=0.026) and mental scores (2 (-3, 9) vs 0 (-4, 5), p=0.004), EQ-5D (0 (0,2) vs 0 (-0.1, 0.1), p=0.027) and Karnofsky functional status scores (10 (0, 10) vs 0 (0, 10), p=0.001) were more favourable in patients without recurrent AT/AF. In the overall cohort, the proportion with at least mild cognitive impairment (Montreal Cognitive Assessment <26) declined from 30.3% (n=157) at baseline to 21.8% (n=113) at follow-up. ANCOVA identified greater improvement in Karnofsky functional status (p<0.001) but not SF-12 physical (p=0.238) or mental scores (p=0.065) in those without recurrent AT/AF compared with patients with recurrent AT/AF. CONCLUSIONS: Patients without recurrent AT/AF appear to experience greater improvement in functional status but similar QoL as those with recurrent AT/AF after AF ablation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Fibrilación Atrial / Ablación por Catéter / Cognición / Estado Funcional Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Heart Asunto de la revista: CARDIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Fibrilación Atrial / Ablación por Catéter / Cognición / Estado Funcional Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Heart Asunto de la revista: CARDIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido