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Role of Lung Microbiome in Innate Immune Response Associated With Chronic Lung Diseases.
Paudel, Keshav Raj; Dharwal, Vivek; Patel, Vyoma K; Galvao, Izabela; Wadhwa, Ridhima; Malyla, Vamshikrishna; Shen, Sj Sijie; Budden, Kurtis F; Hansbro, Nicole G; Vaughan, Annalicia; Yang, Ian A; Kohonen-Corish, Maija R J; Bebawy, Mary; Dua, Kamal; Hansbro, Philip M.
Afiliación
  • Paudel KR; Centre for Inflammation, Centenary Institute, Sydney, NSW, Australia.
  • Dharwal V; Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
  • Patel VK; Centre for Inflammation, Centenary Institute, Sydney, NSW, Australia.
  • Galvao I; Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
  • Wadhwa R; Centre for Inflammation, Centenary Institute, Sydney, NSW, Australia.
  • Malyla V; Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
  • Shen SS; Centre for Inflammation, Centenary Institute, Sydney, NSW, Australia.
  • Budden KF; Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
  • Hansbro NG; Centre for Inflammation, Centenary Institute, Sydney, NSW, Australia.
  • Vaughan A; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia.
  • Yang IA; Centre for Inflammation, Centenary Institute, Sydney, NSW, Australia.
  • Kohonen-Corish MRJ; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia.
  • Bebawy M; Centre for Inflammation, Centenary Institute, Sydney, NSW, Australia.
  • Dua K; Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
  • Hansbro PM; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSW, Australia.
Front Med (Lausanne) ; 7: 554, 2020.
Article en En | MEDLINE | ID: mdl-33043031
Respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung fibrosis, and lung cancer, pose a huge socio-economic burden on society and are one of the leading causes of death worldwide. In the past, culture-dependent techniques could not detect bacteria in the lungs, therefore the lungs were considered a sterile environment. However, the development of culture-independent techniques, particularly 16S rRNA sequencing, allowed for the detection of commensal microbes in the lung and with further investigation, their roles in disease have since emerged. In healthy individuals, the predominant commensal microbes are of phylum Firmicutes and Bacteroidetes, including those of the genera Veillonella and Prevotella. In contrast, pathogenic microbes (Haemophilus, Streptococcus, Klebsiella, Pseudomonas) are often associated with lung diseases. There is growing evidence that microbial metabolites, structural components, and toxins from pathogenic and opportunistic bacteria have the capacity to stimulate both innate and adaptive immune responses, and therefore can contribute to the pathogenesis of lung diseases. Here we review the multiple mechanisms that are altered by pathogenic microbiomes in asthma, COPD, lung cancer, and lung fibrosis. Furthermore, we focus on the recent exciting advancements in therapies that can be used to restore altered microbiomes in the lungs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Front Med (Lausanne) Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Front Med (Lausanne) Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza