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Nonstructured Treatment Interruptions Are Associated With Higher Human Immunodeficiency Virus Reservoir Size Measured by Intact Proviral DNA Assay in People Who Inject Drugs.
Kirk, Gregory D; Astemborski, Jacqueline; Mehta, Shruti H; Ritter, Kristen D; Laird, Gregory M; Bordi, Rebeka; Sekaly, Rafick; Siliciano, Janet D; Siliciano, Robert F.
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  • Kirk GD; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Astemborski J; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Mehta SH; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Ritter KD; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Laird GM; Accelevir Diagnostics, Baltimore, Maryland, USA.
  • Bordi R; Accelevir Diagnostics, Baltimore, Maryland, USA.
  • Sekaly R; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
  • Siliciano JD; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
  • Siliciano RF; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
J Infect Dis ; 223(11): 1905-1913, 2021 06 04.
Article en En | MEDLINE | ID: mdl-33037877
The latent reservoir for human immunodeficiency virus type 1 (HIV-1) in CD4+ T cells is a major barrier to cure. HIV-1-infected persons who inject drugs (PWID) often struggle to maintain suppression of viremia and experience nonstructured treatment interruptions (NTIs). The effects of injecting drugs or NTIs on the reservoir are unclear. Using the intact proviral DNA assay, we found no apparent effect of heroin or cocaine use on reservoir size. However, we found significantly larger reservoirs in those with frequent NTIs or a shorter interval from last detectable HIV RNA measurement. These results have important implications for inclusion of PWID in HIV-1 cure studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Abuso de Sustancias por Vía Intravenosa / Carga Viral / Consumidores de Drogas Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Infect Dis Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Abuso de Sustancias por Vía Intravenosa / Carga Viral / Consumidores de Drogas Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Infect Dis Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos