Methionine aminopeptidases with short sequence inserts within the catalytic domain are differentially inhibited: Structural and biochemical studies of three proteins from Vibrio spp.

Pillalamarri, Vijaykumar; Reddy, Chilakala Gangi; Bala, Sandeep Chowdary; Jangam, Aruna; Kutty, Vinny Vinod; Addlagatta, Anthony

Pillalamarri, Vijaykumar; Reddy, Chilakala Gangi; Bala, Sandeep Chowdary; Jangam, Aruna; Kutty, Vinny Vinod; Addlagatta, Anthony.

Afiliación

Pillalamarri V; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India; CSIR-Indian Institute of Chemical Technology, Department of Applied Biology, Hyderabad, Telangana, 500007, India.
Reddy CG; CSIR-Indian Institute of Chemical Technology, Department of Applied Biology, Hyderabad, Telangana, 500007, India.
Bala SC; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India; CSIR-Indian Institute of Chemical Technology, Department of Applied Biology, Hyderabad, Telangana, 500007, India.
Jangam A; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India; CSIR-Indian Institute of Chemical Technology, Department of Applied Biology, Hyderabad, Telangana, 500007, India.
Kutty VV; CSIR-Indian Institute of Chemical Technology, Department of Applied Biology, Hyderabad, Telangana, 500007, India.
Addlagatta A; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India; CSIR-Indian Institute of Chemical Technology, Department of Applied Biology, Hyderabad, Telangana, 500007, India. Electronic address: anthony@iict.res.in.

Eur J Med Chem ; 209: 112883, 2021 Jan 01.

Article en En | MEDLINE | ID: mdl-33035924

Asunto(s)

Proteínas Bacterianas/antagonistas & inhibidores; Inhibidores Enzimáticos/química; Inhibidores Enzimáticos/farmacología; Metionil Aminopeptidasas/antagonistas & inhibidores; Vibrio/enzimología; Secuencia de Aminoácidos; Antibacterianos/química; Antibacterianos/farmacología; Proteínas Bacterianas/química; Proteínas Bacterianas/metabolismo; Dominio Catalítico/efectos de los fármacos; Cristalografía por Rayos X; Humanos; Metionil Aminopeptidasas/química; Metionil Aminopeptidasas/metabolismo; Simulación del Acoplamiento Molecular; Isoformas de Proteínas/antagonistas & inhibidores; Isoformas de Proteínas/química; Isoformas de Proteínas/metabolismo; Pirimidinas/química; Pirimidinas/farmacología; Vibrio/química; Vibrio/metabolismo

Palabras clave

Cholera; Drug discovery; MetAP; Methionine aminopeptidase; Vibrio

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Vibrio / Inhibidores Enzimáticos / Metionil Aminopeptidasas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: India Pais de publicación: Francia

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