The antibiotic crisis: How bacterial predators can help.
Comput Struct Biotechnol J
; 18: 2547-2555, 2020.
Article
en En
| MEDLINE
| ID: mdl-33033577
Discovery of antimicrobials in the past century represented one of the most important advances in public health. Unfortunately, the massive use of these compounds in medicine and other human activities has promoted the selection of pathogens that are resistant to one or several antibiotics. The current antibiotic crisis is creating an urgent need for research into new biological weapons with the ability to kill these superbugs. Although a proper solution requires this problem to be addressed in a variety of ways, the use of bacterial predators is emerging as an excellent strategy, especially when used as whole cell therapeutic agents, as a source of new antimicrobial agents by awakening silent metabolic pathways in axenic cultures, or as biocontrol agents. Moreover, studies on their prey are uncovering mechanisms of resistance that can be shared by pathogens, representing new targets for novel antimicrobial agents. In this review we discuss potential of the studies on predator-prey interaction to provide alternative solutions to the problem of antibiotic resistance.
AR, antibiotic resistance; ARB, antibiotic-resistant bacteria; ARG, antibiotic-resistant gene; Antibiotic crisis; BALOs; BALOs, Bdellovibrio and like organisms; BGC, biosynthetic gene cluster; Bacterial predators; HGT, horizontal gene transfer; MDRB, multi-drug resistant bacteria; Myxobacteria; NRPS, nonribosomal peptide synthetase; OMV, outer membrane vesicle; OSMAC, one strain many compounds; PKS, polyketide synthase; SM, secondary metabolite; WHO, World Health Organization
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Comput Struct Biotechnol J
Año:
2020
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Países Bajos