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Functionalized Scaffold and Barrier Membrane with Anti-BMP-2 Monoclonal Antibodies for Alveolar Ridge Preservation in a Canine Model.
Min, Seiko; Kim, Taewan; Kim, Oksu; Goncalo, Carames; Utsunomiya, Tadahiko; Matsumoto, Takashi; Kuyama, Kayo; Angelov, Nikola.
Afiliación
  • Min S; Department of Periodontics and Dental Hygiene, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Kim T; Department of Periodontics, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
  • Kim O; Department of Periodontology, Dental Research Institute, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.
  • Goncalo C; Department of Periodontology, Implantology Institute, Lisbon, Portugal.
  • Utsunomiya T; Department of Pathology, School of Dentistry, Nihon University at Matsudo, Chiba, Japan.
  • Matsumoto T; Division of Diagnostic Pathology, Nihon University Hospital School of Dentistry at Matsudo, Chiba, Japan.
  • Kuyama K; Department of Pathology, School of Dentistry, Nihon University at Matsudo, Chiba, Japan.
  • Angelov N; Department of Periodontics and Dental Hygiene, University of Texas Health Science Center at Houston, Houston, TX, USA.
Biomed Res Int ; 2020: 6153724, 2020.
Article en En | MEDLINE | ID: mdl-33029518
INTRODUCTION: The aim of this study was to investigate the ability of anti-bone morphogenetic protein 2 monoclonal antibody (anti-BMP-2 mAb) to functionalize scaffolds to mediate bone regeneration in a canine model. MATERIALS AND METHODS: The mandibular right premolar 4 (PM4) was extracted in eight beagle dogs and grafted with anti-BMP-2 mAb+anorganic bovine bone mineral with 10% collagen (ABBM-C) and porcine bilayer native collagen membrane (CM). The ABBM-C and CM were functionalized with either anti-BMP-2 mAb (test group) or an isotype matched control mAb (control group). Animals were euthanized at 12 weeks for radiographic, histologic, and histomorphometric analyses. Outcomes were compared between groups. RESULTS: 3D imaging using cone beam computed tomography (CBCT) revealed that sites treated with ABBM-C and CM functionalized with anti-BMP-2 mAb exhibited significantly more remaining bone width near the alveolar crest, as well as buccal bone height, compared with control groups. Histologic and histomorphometric analyses demonstrated that in anti-BMP-2 mAb-treated sites, total tissue volume was significantly higher in the coronal part of the alveolar bone crest compared with control sites. In anti-BMP-2 mAb-treated sites, bone formation was observed under the barrier membrane. CONCLUSION: Functionalization of the ABBM-C scaffold and CM appeared to have led to bone formation within healing alveolar bone sockets.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Andamios del Tejido / Proteína Morfogenética Ósea 2 / Proceso Alveolar / Anticuerpos Monoclonales Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Andamios del Tejido / Proteína Morfogenética Ósea 2 / Proceso Alveolar / Anticuerpos Monoclonales Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos