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Machine learning integration of scleroderma histology and gene expression identifies fibroblast polarisation as a hallmark of clinical severity and improvement.
Showalter, Kimberly; Spiera, Robert; Magro, Cynthia; Agius, Phaedra; Martyanov, Viktor; Franks, Jennifer M; Sharma, Roshan; Geiger, Heather; Wood, Tammara A; Zhang, Yaxia; Hale, Caryn R; Finik, Jackie; Whitfield, Michael L; Orange, Dana E; Gordon, Jessica K.
Afiliación
  • Showalter K; Department of Medicine, Division of Rheumatology, Hospital for Special Surgery, New York, New York, USA showalterk@hss.edu.
  • Spiera R; Department of Medicine, Division of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
  • Magro C; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA.
  • Agius P; New York Genome Center, New York, New York, USA.
  • Martyanov V; Molecular and Systems Biology, Dartmouth College Geisel School of Medicine, Hanover, New Hampshire, USA.
  • Franks JM; Biomedical Data Science, Dartmouth College Geisel School of Medicine, Hanover, New Hampshire, USA.
  • Sharma R; Molecular and Systems Biology, Dartmouth College Geisel School of Medicine, Hanover, New Hampshire, USA.
  • Geiger H; Biomedical Data Science, Dartmouth College Geisel School of Medicine, Hanover, New Hampshire, USA.
  • Wood TA; New York Genome Center, New York, New York, USA.
  • Zhang Y; New York Genome Center, New York, New York, USA.
  • Hale CR; Molecular and Systems Biology, Dartmouth College Geisel School of Medicine, Hanover, New Hampshire, USA.
  • Finik J; Biomedical Data Science, Dartmouth College Geisel School of Medicine, Hanover, New Hampshire, USA.
  • Whitfield ML; Department of Pathology, Hospital for Special Surgery, New York, New York, USA.
  • Orange DE; Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA.
  • Gordon JK; Department of Medicine, Hospital for Special Surgery, New York, New York, USA.
Ann Rheum Dis ; 80(2): 228-237, 2021 02.
Article en En | MEDLINE | ID: mdl-33028580
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Severidad de la Enfermedad / Esclerodermia Difusa / Fibroblastos / Aprendizaje Automático Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Rheum Dis Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Severidad de la Enfermedad / Esclerodermia Difusa / Fibroblastos / Aprendizaje Automático Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Rheum Dis Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido