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Tailoring Cu substituted hydroxyapatite/functionalized multiwalled carbon nanotube composite coating on 316L SS implant for enhanced corrosion resistance, antibacterial and bioactive properties.
Sivaraj, Durairaj; Vijayalakshmi, Kalimuthu; Ganeshkumar, Arumugam; Rajaram, Rajendran.
Afiliación
  • Sivaraj D; Research Department of Physics, Bishop Heber College, Tiruchirappalli, Tamil Nadu, India; SSN Research Centre, SSN College of Engineering, Kalavakkam, Chennai, Tamilnadu 603 110, India. Electronic address: siva191091@gmail.com.
  • Vijayalakshmi K; Research Department of Physics, Bishop Heber College, Tiruchirappalli, Tamil Nadu, India. Electronic address: viji71naveen@yahoo.com.
  • Ganeshkumar A; DNA Barcoding and Marine Genomics Laboratory, Department of Marine Science, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
  • Rajaram R; DNA Barcoding and Marine Genomics Laboratory, Department of Marine Science, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
Int J Pharm ; 590: 119946, 2020 Nov 30.
Article en En | MEDLINE | ID: mdl-33027634
The aim of the present work is to study the potential change in the antibacterial properties of Cu-hydroxyapatite/functionalized multiwall carbon nanotube (HA/f-MWCNT) composite coated heterogeneous implant surfaces against Gram positive and Gram-negative microorganism and to reveal the possible contribution of surface corrosion effects arising in stimulated body fluid. Novel spray pyrolysis instrument designed with double nozzle was used for the fabrication of Cu-hydroxyapatite/f-MWCNT film on 316L stainless steel (SS). The Cu-hydroxyapatite/MWCNT coated bioimplant was characterized by a series of techniques to identify the crystallinity, chemical bonds, surface morphology and elemental composition. The results disclose that the coated implants exhibit highly crystalline nature with the space group of P63mc and spherical shaped morphology. The corrosion current density revealed a remarkable decrease from 6.8 to 3.8 µA suggesting that the Cu substituted hydroxyapatite/f-MWCNT composite coating provided higher barrier properties which is beneficial to achieve higher corrosion protection of 316L SS implant. The hybrid Cu-hydroxyapatite-MWCNT composite revealed better antibacterial ability than HA/MWCNT for both gram positive and gram-negative bacteria with a maximum inhibition zone of 13-17 mm, compared with hydroxyapatite/f-MWCNT. The antibacterial ability of the Cu-hydroxyapatite/f-MWCNT nanocomposites was effective against Escherichia coli compared with other microorganisms. The Cu-hydroxyapatite/f-MWCNT nanocomposite exhibited that the coated material is nontoxic, biocompatible and suitable for biomedical application.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acero Inoxidable / Nanotubos de Carbono Idioma: En Revista: Int J Pharm Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acero Inoxidable / Nanotubos de Carbono Idioma: En Revista: Int J Pharm Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos