Your browser doesn't support javascript.
loading
Validation of Nine Different Prognostic Grading Indexes for Radiosurgery of Brain Metastases in Breast Cancer Patients and Development of an All-Encompassing Prognostic Tool.
Weykamp, Fabian; El Shafie, Rami A; König, Laila; Seidensaal, Katharina; Forster, Tobias; Arians, Nathalie; Regnery, Sebastian; Hoegen, Philipp; Deutsch, Thomas M; Schneeweiss, Andreas; Debus, Jürgen; Hörner-Rieber, Juliane.
Afiliación
  • Weykamp F; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
  • El Shafie RA; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany.
  • König L; Department of Obstetrics and Gynecology, Heidelberg University Hospital, Heidelberg, Germany.
  • Seidensaal K; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
  • Forster T; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany.
  • Arians N; Department of Obstetrics and Gynecology, Heidelberg University Hospital, Heidelberg, Germany.
  • Regnery S; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
  • Hoegen P; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany.
  • Deutsch TM; Department of Obstetrics and Gynecology, Heidelberg University Hospital, Heidelberg, Germany.
  • Schneeweiss A; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
  • Debus J; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany.
  • Hörner-Rieber J; Department of Obstetrics and Gynecology, Heidelberg University Hospital, Heidelberg, Germany.
Front Oncol ; 10: 1557, 2020.
Article en En | MEDLINE | ID: mdl-33014802
Purpose: Several prognostic indexes for overall survival (OS) after radiotherapy of brain metastases in breast cancer patients exist but are mainly validated for whole-brain radiotherapy or not specifically for breast cancer patients. To date, no such index provides information beyond mere OS. Methods: We retrospectively analyzed 95 breast cancer patients treated with stereotactic radiosurgery for 203 brain metastases. The Kaplan-Meier method with log-rank test was used to assess OS, local control (LC), distant cranial control (DCC), and extracranial control (EC). Cox regression was applied to detect prognostic outcome factors. A point scoring system was designed to stratify patients based on outcome. Nine established prognostic indexes were analyzed using the concordance index (c-index). Results: Two out of nine analyzed prognostic indexes for OS showed a significant c-index, the breast graded prognostic assessment (bGPA; 0.631; 95% CI, 0.514-0.748; p = 0.037) and the modified bGPA (mod-bGPA; 0.662; 95% CI, 0.547-0.777; p = 0.010). Significant results from multivariate analysis (Karnofsky Performance Score, Her2/neu receptor status, extracranial control) were used to generate a new point system: the breast cancer stereotactic radiotherapy score (bSRS), which discriminated three significantly different prognostic groups, for LC, DCC, EC, and OS, respectively. However, the c-index was only significant for OS (0.689; 95% CI, 0.577-0.802; p = 0.003). Conclusions: The new bSRS score was superior to the bGPA and mod-bGPA scores for prognosis of OS. The bSRS is easy to use and the first tool, which might also provide outcome assessment beyond mere OS. Future studies need to validate these findings.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Oncol Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Oncol Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza