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Ticagrelor prevents tumor metastasis via inhibiting cell proliferation and promoting platelet apoptosis.
Meng, Xingjun; Liu, Weisheng; Yang, Hui; Cao, Zhihui; He, Hui; Zheng, Kai; Chen, Yonghua; Su, Jiang; Lv, Jun; Sun, Jiantong; Li, Ping; Ding, Shuai; Ahmad, N; Qian, Jun; Zhou, Yuanshuai.
Afiliación
  • Meng X; The Affiliated Suzhou Hospital of Nanjing Medical University.
  • Liu W; The Affiliated Suzhou Hospital of Nanjing Medical University.
  • Yang H; The Affiliated Suzhou Hospital of Nanjing Medical University.
  • Cao Z; The Affiliated Suzhou Hospital of Nanjing Medical University.
  • He H; The Affiliated Suzhou Hospital of Nanjing Medical University.
  • Zheng K; The Affiliated Suzhou Hospital of Nanjing Medical University.
  • Chen Y; The Affiliated Suzhou Hospital of Nanjing Medical University.
  • Su J; The Affiliated Suzhou Hospital of Nanjing Medical University.
  • Lv J; The Affiliated Suzhou Hospital of Nanjing Medical University.
  • Sun J; The Affiliated Suzhou Hospital of Nanjing Medical University.
  • Li P; The Affiliated Suzhou Hospital of Nanjing Medical University.
  • Ding S; Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China.
  • Ahmad N; Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan.
  • Qian J; The Affiliated Suzhou Hospital of Nanjing Medical University.
  • Zhou Y; Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China.
Anticancer Drugs ; 31(10): 1012-1017, 2020 11.
Article en En | MEDLINE | ID: mdl-33009034
Tumor cells can activate platelets, which in turn facilitate tumor cell survival and dissemination. Platelets inhibition or blocking platelet-tumor cell interactions has become a strategy to suppress tumor progression. In this study, we investigated the effect of ticagrelor, a new antiplatelet drug, on tumor cell proliferation and metastasis. Our results show that ticagrelor not only inhibits the proliferation, migration, and invasion of B16F10 and Lewis lung carcinoma cells but also induces platelet apoptosis. In addition, we find that apoptosis of the platelet cells is dose dependent. Further, the result of in-vivo experiments proved that ticagrelor treatment decreased the tumor metastasis. The results of this study demonstrate that ticagrelor may be a potential anti-tumor agent for tumor metastasis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaquetas / Melanoma Experimental / Inhibidores de Agregación Plaquetaria / Carcinoma Pulmonar de Lewis / Ticagrelor / Antineoplásicos Límite: Animals Idioma: En Revista: Anticancer Drugs Asunto de la revista: ANTINEOPLASICOS Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaquetas / Melanoma Experimental / Inhibidores de Agregación Plaquetaria / Carcinoma Pulmonar de Lewis / Ticagrelor / Antineoplásicos Límite: Animals Idioma: En Revista: Anticancer Drugs Asunto de la revista: ANTINEOPLASICOS Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido