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Genome-wide association study reveals genes associated with the absence of intermuscular bones in tambaqui (Colossoma macropomum).
Nunes, J R S; Pértille, F; Andrade, S C S; Perazza, C A; Villela, P M S; Almeida-Val, V M F; Gao, Z-X; Coutinho, L L; Hilsdorf, A W S.
Afiliación
  • Nunes JRS; Nature and Culture Institute, Federal University of Amazon (UFAM), Benjamin Constant, Amazonas, 69630-000, Brazil.
  • Pértille F; Animal Science Department, University of São Paulo (USP)/Luiz de Queiroz College of Agriculture (ESALQ), Piracicaba, São Paulo, 13418-900, Brazil.
  • Andrade SCS; Animal Science Department, University of São Paulo (USP)/Luiz de Queiroz College of Agriculture (ESALQ), Piracicaba, São Paulo, 13418-900, Brazil.
  • Perazza CA; Avian Behavioural Genomics and Physiology Group, IFM Biology, Linköping University, Linköping, 58 183, Sweden.
  • Villela PMS; Genetics and Evolutionary Biology Department, University of São Paulo (USP)/Bioscience Institute (IB), São Paulo, São Paulo, 05508-090, Brazil.
  • Almeida-Val VMF; Unit of Biotechnology, University of Mogi das Cruzes, Mogi das Cruzes, São Paulo, 08780-911, Brazil.
  • Gao ZX; Animal Science Department, University of São Paulo (USP)/Luiz de Queiroz College of Agriculture (ESALQ), Piracicaba, São Paulo, 13418-900, Brazil.
  • Coutinho LL; Brazilian National Institute for Research of the Amazon, Laboratory of Ecophysiology and Molecular Evolution, Manaus, Amazonas, 69067-375, Brazil.
  • Hilsdorf AWS; College of Fisheries, Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education/Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Huazhong Agricultural University, Hongshan District, Wuhan, 430070, China.
Anim Genet ; 51(6): 899-909, 2020 Dec.
Article en En | MEDLINE | ID: mdl-33006182
The presence of intermuscular bones in fisheries products limits the consumption and commercialization potential of many fish species, including tambaqui (Colossoma macropomum). These bones have caused medical emergencies and are an undesirable characteristic for fish farming because their removal is labor-intensive during fish processing. Despite the difficulty in identifying genes related to the lack of intermuscular bone in diverse species of fish, the discovery of individuals lacking intermuscular bones in a Neotropical freshwater characiform fish has provided a unique opportunity to delve into the genetic mechanisms underlying the pathways of intermuscular bone formation. In this study, we carried out a GWAS among boneless and wt tambaqui populations to identify markers associated with a lack of intermuscular bone. After analyzing 11 416 SNPs in 360 individuals (12 boneless and 348 bony), we report 675 significant (Padj  < 0.003) associations for this trait. Of those, 13 associations were located near candidate genes related to the reduction of bone mass, promotion of bone formation, inhibition of bone resorption, central control of bone remodeling, bone mineralization and other related functions. To the best of our knowledge, for the first time, we have successfully identified genes related to a lack of intermuscular bones using GWAS in a non-model species.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteogénesis / Huesos / Estudios de Asociación Genética / Characiformes Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: Anim Genet Asunto de la revista: GENETICA / MEDICINA VETERINARIA Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteogénesis / Huesos / Estudios de Asociación Genética / Characiformes Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: Anim Genet Asunto de la revista: GENETICA / MEDICINA VETERINARIA Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido