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Radionecrosis and cellular changes in small volume stereotactic brain radiosurgery in a porcine model.
Zaer, Hamed; Glud, Andreas Nørgaard; Schneider, Bret M; Lukacova, Slávka; Vang Hansen, Kim; Adler, John R; Høyer, Morten; Jensen, Morten Bjørn; Hansen, Rune; Hoffmann, Lone; Worm, Esben Schjødt; Sørensen, Jens Chr Hedemann; Orlowski, Dariusz.
Afiliación
  • Zaer H; Centre for Experimental Neuroscience (CENSE), Department of Neurosurgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, indgang J, Plan 1, J118-125, (Krydspunkt 116), 8200, Aarhus N, Denmark. hz@clin.au.dk.
  • Glud AN; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. hz@clin.au.dk.
  • Schneider BM; Centre for Experimental Neuroscience (CENSE), Department of Neurosurgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, indgang J, Plan 1, J118-125, (Krydspunkt 116), 8200, Aarhus N, Denmark.
  • Lukacova S; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Vang Hansen K; Zap Surgical Systems, Inc., San Carlos, CA, USA.
  • Adler JR; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Høyer M; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
  • Jensen MB; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Hansen R; Department of Oncology and Radiation Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Hoffmann L; Department of Nuclear Medicine and PET Center, Institute of Clinical Medicine, Aarhus University and Hospital, Aarhus, Denmark.
  • Worm ES; Zap Surgical Systems, Inc., San Carlos, CA, USA.
  • Sørensen JCH; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Orlowski D; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Sci Rep ; 10(1): 16223, 2020 10 01.
Article en En | MEDLINE | ID: mdl-33004849
Stereotactic radiosurgery (SRS) has proven an effective tool for the treatment of brain tumors, arteriovenous malformation, and functional conditions. However, radiation-induced therapeutic effect in viable cells in functional SRS is also suggested. Evaluation of the proposed modulatory effect of irradiation on neuronal activity without causing cellular death requires the knowledge of radiation dose tolerance at very small tissue volume. Therefore, we aimed to establish a porcine model to study the effects of ultra-high radiosurgical doses in small volumes of the brain. Five minipigs received focal stereotactic radiosurgery with single large doses of 40-100 Gy to 5-7.5 mm fields in the left primary motor cortex and the right subcortical white matter, and one animal remained as unirradiated control. The animals were followed-up with serial MRI, PET scans, and histology 6 months post-radiation. We observed a dose-dependent relation of the histological and MRI changes at 6 months post-radiation. The necrotic lesions were seen in the grey matter at 100 Gy and in white matter at 60 Gy. Furthermore, small volume radiosurgery at different dose levels induced vascular, as well as neuronal cell changes and glial cell remodeling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos por Radiación / Encéfalo / Radiocirugia / Necrosis Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos por Radiación / Encéfalo / Radiocirugia / Necrosis Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido