Synthesis, <i>in vitro</i> inhibitory activity, kinetic study and molecular docking of novel <i>N</i>-alkyl-deoxynojirimycin derivatives as potential &#945;-glucosidase inhibitors.

Lin, Ping; Zeng, Jia-Cheng; Chen, Ji-Guang; Nie, Xu-Liang; Yuan, En; Wang, Xiao-Qiang; Peng, Da-Yong; Yin, Zhong-Ping

Synthesis, in vitro inhibitory activity, kinetic study and molecular docking of novel N-alkyl-deoxynojirimycin derivatives as potential α-glucosidase inhibitors.

Lin, Ping; Zeng, Jia-Cheng; Chen, Ji-Guang; Nie, Xu-Liang; Yuan, En; Wang, Xiao-Qiang; Peng, Da-Yong; Yin, Zhong-Ping.

Afiliación

Lin P; Jiangxi Key Laboratory of Natural Products and Functional Foods, Jiangxi Agricultural University, Nanchang, China.
Zeng JC; Jiangxi Key Laboratory of Natural Products and Functional Foods, Jiangxi Agricultural University, Nanchang, China.
Chen JG; Jiangxi Key Laboratory of Natural Products and Functional Foods, Jiangxi Agricultural University, Nanchang, China.
Nie XL; College of Science, Jiangxi Agricultural University, Nanchang, China.
Yuan E; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Wang XQ; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China.
Peng DY; College of Science, Jiangxi Agricultural University, Nanchang, China.
Yin ZP; Jiangxi Key Laboratory of Natural Products and Functional Foods, Jiangxi Agricultural University, Nanchang, China.

J Enzyme Inhib Med Chem ; 35(1): 1879-1890, 2020 Dec.

Article en En | MEDLINE | ID: mdl-33003963

Asunto(s)

Glucosamina/análogos & derivados; Inhibidores de Glicósido Hidrolasas/síntesis química; alfa-Glucosidasas/metabolismo; 1-Desoxinojirimicina/síntesis química; 1-Desoxinojirimicina/farmacocinética; Acarbosa/farmacología; Acarbosa/normas; Compuestos de Bencilideno/química; Glucosamina/síntesis química; Glucosamina/farmacocinética; Inhibidores de Glicósido Hidrolasas/farmacocinética; Humanos; Enlace de Hidrógeno; Interacciones Hidrofóbicas e Hidrofílicas; Cinética; Simulación del Acoplamiento Molecular; Relación Estructura-Actividad

Palabras clave

1-Deoxynojirimycin derivatives; docking study; inhibitor; structureactivity relationship; α-glucosidase

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alfa-Glucosidasas / Inhibidores de Glicósido Hidrolasas / Glucosamina Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google