Effects of botulinum toxin A on endometriosisassociated pain and its related mechanism.
Mol Med Rep
; 22(5): 4351-4359, 2020 Nov.
Article
en En
| MEDLINE
| ID: mdl-33000241
Endometriosis (EMS) is a common disease in women aged 2545 years, and pain is the main clinical symptom. The primary clinical treatment is surgical excision and drug therapy targeting the ectopic lesions, but these have not been very effective. Botulinum neurotoxin serotype A (BTXA) has been reported to be useful in the treatment of pain in a variety of diseases. Based on this, the aim of the present study was to explore the therapeutic effect and mechanism of BTXA on EMS. A model of nerve injury induced by oxygen glucose deprivation (OGD) was constructed in PC12 cells and EMS mice. Model cells and mice were treated with different concentrations of BTXA to observe the changes in pain behavior, to detect cell viability and the secretion of norepinephrine (NE) and methionine enkephalin (MEK) in cells and the spinal cord, and to evaluate the expression of apoptosisrelated molecules in spinal cord nerves. The results revealed that BTXA significantly reduced the amount of writhing in model mice, enhanced the activity of PC12 OGD cells, increased the secretion of NE and MEK in model cells and the spinal cord of mice, and decreased the apoptosis of neural cells in the spinal cord of the model mice. Therefore, it was hypothesized that BTXA may alleviate the pain induced by EMS by increasing the secretion of analgesic substances and promoting the repair of nerve injury. The present study provided a theoretical basis for the treatment of pain induced by EMS.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Encefalina Metionina
/
Norepinefrina
/
Toxinas Botulínicas Tipo A
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Endometriosis
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
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Animals
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Female
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Humans
Idioma:
En
Revista:
Mol Med Rep
Año:
2020
Tipo del documento:
Article
Pais de publicación:
Grecia