Discovery, biological evaluation and docking studies of novel N-acyl-2-aminothiazoles fused (+)-nootkatone from Citrus paradisi Macf. as potential &#945;-glucosidase inhibitors.

Guo, Yong; Hou, Enhua; Ma, Nannan; Liu, Zhiyan; Fan, Jiangping; Yang, Ruige

Discovery, biological evaluation and docking studies of novel N-acyl-2-aminothiazoles fused (+)-nootkatone from Citrus paradisi Macf. as potential α-glucosidase inhibitors.

Guo, Yong; Hou, Enhua; Ma, Nannan; Liu, Zhiyan; Fan, Jiangping; Yang, Ruige.

Afiliación

Guo Y; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, No. 100, KeXue Avenue, Zhengzhou 450001, Henan Province, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research
Hou E; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, No. 100, KeXue Avenue, Zhengzhou 450001, Henan Province, China.
Ma N; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, No. 100, KeXue Avenue, Zhengzhou 450001, Henan Province, China.
Liu Z; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, No. 100, KeXue Avenue, Zhengzhou 450001, Henan Province, China.
Fan J; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, No. 100, KeXue Avenue, Zhengzhou 450001, Henan Province, China.
Yang R; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, No. 100, KeXue Avenue, Zhengzhou 450001, Henan Province, China. Electronic address: yrggg@163.com.

Bioorg Chem ; 104: 104294, 2020 11.

Article en En | MEDLINE | ID: mdl-32987307

Asunto(s)

Citrus paradisi/química; Descubrimiento de Drogas; Inhibidores de Glicósido Hidrolasas/farmacología; Simulación del Acoplamiento Molecular; Sesquiterpenos Policíclicos/farmacología; Tiazoles/farmacología; Relación Dosis-Respuesta a Droga; Inhibidores de Glicósido Hidrolasas/química; Inhibidores de Glicósido Hidrolasas/aislamiento & purificación; Estructura Molecular; Sesquiterpenos Policíclicos/química; Sesquiterpenos Policíclicos/aislamiento & purificación; Saccharomyces cerevisiae/enzimología; Relación Estructura-Actividad; Tiazoles/química; Tiazoles/aislamiento & purificación; alfa-Glucosidasas/metabolismo

Palabras clave

(+)-Nootkatone; Cytotoxicity; Molecular docking; Thiazole; Type-2 diabetes; α-Glucosidase inhibitor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiazoles / Citrus paradisi / Descubrimiento de Drogas / Simulación del Acoplamiento Molecular / Inhibidores de Glicósido Hidrolasas / Sesquiterpenos Policíclicos Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos

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