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Interleukin-17 and Interleukin-10 Association with Disease Progression in Schizophrenia.
Chenniappan, Raghavi; Nandeesha, Hanumanthappa; Kattimani, Shivanand; Nanjaiah, Nandakumar Dalavaikodihalli.
Afiliación
  • Chenniappan R; Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
  • Nandeesha H; Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
  • Kattimani S; Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
  • Nanjaiah ND; Department of Neurochemistry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India.
Ann Neurosci ; 27(1): 24-28, 2020 Jan.
Article en En | MEDLINE | ID: mdl-32982096
BACKGROUND: Alteration in cytokine levels are known to be involved in the pathogenesis of schizophrenia. OBJECTIVES: To estimate the serum levels of interleukin-17 (IL-17) and interleukin-10 (IL-10) and their association with disease progression in schizophrenia. METHODS: A total of 67 schizophrenia cases were enrolled in the present study. IL-17 and IL-10 were estimated by enzyme-linked immunosorbent assay. Positive and Negative Syndrome Scale (PANSS) was used to evaluate disease severity. RESULTS: IL-17 was positively correlated with positive symptom score (r = 0.256, p = .036), general psychopathology score (r = 0.255, p = .038) and total score (r = 0.273, p = .025) in schizophrenia. IL-17 and IL-10 were significantly increased in schizophrenia cases with PANSS more than 85 compared to those with 71-85. CONCLUSION: IL-17 and IL-10 are associated with disease severity in schizophrenia but are not good markers for predicting the disease progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Ann Neurosci Año: 2020 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Ann Neurosci Año: 2020 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos