Potential therapeutic role of fibroblast growth factor 21 in neurodegeneration: Evidence for ameliorating parkinsonism via silent information regulator 2 homolog 1 and implication for gene therapy.

Chen, Yingjie; Shen, Jie; Qi, Guixia; Zha, Qian; Zhang, Chen; Yao, Wenbing; Gao, Xiangdong; Chen, Song

Chen, Yingjie; Shen, Jie; Qi, Guixia; Zha, Qian; Zhang, Chen; Yao, Wenbing; Gao, Xiangdong; Chen, Song.

Afiliación

Chen Y; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, PR China.
Shen J; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, PR China.
Qi G; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, PR China.
Zha Q; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, PR China.
Zhang C; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, PR China.
Yao W; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, PR China.
Gao X; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: xdgao@cpu.edu.cn.
Chen S; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: ChenS@cpu.edu.cn.

Neuropharmacology ; 181: 108335, 2020 12 15.

Article en En | MEDLINE | ID: mdl-32979381

Asunto(s)

Factores de Crecimiento de Fibroblastos/genética; Terapia Genética/métodos; Enfermedades Neurodegenerativas/genética; Enfermedad de Parkinson Secundaria/genética; Enfermedad de Parkinson Secundaria/terapia; Sirtuina 1/genética; Animales; Autofagia/efectos de los fármacos; Conducta Animal/efectos de los fármacos; Neuronas Dopaminérgicas/patología; Humanos; Intoxicación por MPTP/genética; Intoxicación por MPTP/patología; Intoxicación por MPTP/terapia; Masculino; Ratones; Ratones Endogámicos C57BL; Neuroprotección; Enfermedad de Parkinson Secundaria/patología; Proteínas Recombinantes/uso terapéutico; Sirtuina 1/efectos de los fármacos; alfa-Sinucleína/genética

Palabras clave

Dopaminergic neurodegeneration; Fibroblast growth factor 21; Gene therapy; Parkinson's disease; Silent information regulator 2 homolog 1

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Secundaria / Terapia Genética / Enfermedades Neurodegenerativas / Sirtuina 1 / Factores de Crecimiento de Fibroblastos Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Neuropharmacology Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google