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Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing.
Nguyen Tran, Minh Thuan; Mohd Khalid, Mohd Khairul Nizam; Wang, Qi; Walker, Jacqueline K R; Lidgerwood, Grace E; Dilworth, Kimberley L; Lisowski, Leszek; Pébay, Alice; Hewitt, Alex W.
Afiliación
  • Nguyen Tran MT; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Tasmania, Australia. pherominh1@gmail.com.
  • Mohd Khalid MKN; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Tasmania, Australia.
  • Wang Q; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Tasmania, Australia.
  • Walker JKR; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Tasmania, Australia.
  • Lidgerwood GE; Department of Surgery, The University of Melbourne, Victoria, Australia.
  • Dilworth KL; Department of Anatomy and Neuroscience, The University of Melbourne, Victoria, Australia.
  • Lisowski L; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia.
  • Pébay A; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia.
  • Hewitt AW; Military Institute of Hygiene and Epidemiology, The Biological Threats Identification and Countermeasure Centre, Pulawy, Poland.
Nat Commun ; 11(1): 4871, 2020 09 25.
Article en En | MEDLINE | ID: mdl-32978399
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN / Adenina / Ingeniería Genética / Sistemas CRISPR-Cas / Edición Génica Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN / Adenina / Ingeniería Genética / Sistemas CRISPR-Cas / Edición Génica Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido