Downregulation of Caveolin-1 and Upregulation of Deiodinase 3, Associated with Hypoxia-Inducible Factor-1&#945; Increase, Are Involved in the Oxidative Stress of Graves' Orbital Adipocytes.

Van Regemorter, Elliott; Joris, Virginie; Van Regemorter, Victoria; Marique, Lancelot; Behets, Catherine; Lengelé, Benoit; Boschi, Antonella; Baldeschi, Lelio; Daumerie, Chantal; Many, Marie-Christine; Craps, Julie

Downregulation of Caveolin-1 and Upregulation of Deiodinase 3, Associated with Hypoxia-Inducible Factor-1α Increase, Are Involved in the Oxidative Stress of Graves' Orbital Adipocytes.

Van Regemorter, Elliott; Joris, Virginie; Van Regemorter, Victoria; Marique, Lancelot; Behets, Catherine; Lengelé, Benoit; Boschi, Antonella; Baldeschi, Lelio; Daumerie, Chantal; Many, Marie-Christine; Craps, Julie.

Afiliación

Van Regemorter E; Pole of Morphology, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium.
Joris V; Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium.
Van Regemorter V; Pole of Morphology, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium.
Marique L; Pole of Morphology, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium.
Behets C; Pole of Morphology, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium.
Lengelé B; Pole of Morphology, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium.
Boschi A; Department of Ophthalmology and Faculty of Medicine, Université catholique de Louvain, Brussels, Belgium.
Baldeschi L; Department of Ophthalmology and Faculty of Medicine, Université catholique de Louvain, Brussels, Belgium.
Daumerie C; Department of Endocrinology, Faculty of Medicine, Université catholique de Louvain, Brussels, Belgium.
Many MC; Pole of Morphology, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium.
Craps J; Pole of Morphology, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium.

Thyroid ; 31(4): 627-637, 2021 04.

Article en En | MEDLINE | ID: mdl-32977740

Asunto(s)

Adipocitos/enzimología; Caveolina 1/metabolismo; Oftalmopatía de Graves/enzimología; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Yoduro Peroxidasa/metabolismo; Estrés Oxidativo; Adipocitos/patología; Adulto; Estudios de Casos y Controles; Caveolina 1/genética; Células Cultivadas; Femenino; Regulación de la Expresión Génica; Transportador de Glucosa de Tipo 4/metabolismo; Oftalmopatía de Graves/genética; Oftalmopatía de Graves/patología; Humanos; Subunidad alfa del Factor 1 Inducible por Hipoxia/genética; Yoduro Peroxidasa/genética; Masculino; Persona de Mediana Edad; NADPH Oxidasa 2/metabolismo; Óxido Nítrico/metabolismo; Óxido Nítrico Sintasa de Tipo III/metabolismo; Superóxidos/metabolismo; Triyodotironina/metabolismo

Palabras clave

Graves' orbitopathy; HIF-1α; caveolin-1; deiodinase 3; eNOS; oxidative stress

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adipocitos / Estrés Oxidativo / Oftalmopatía de Graves / Caveolina 1 / Subunidad alfa del Factor 1 Inducible por Hipoxia / Yoduro Peroxidasa Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Thyroid Asunto de la revista: ENDOCRINOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos

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