Utility of Three-Dimensional Cultures of Primary Human Hepatocytes (Spheroids) as Pharmacokinetic Models.

Mizoi, Kenta; Arakawa, Hiroshi; Yano, Kentaro; Koyama, Satoshi; Kojima, Hajime; Ogihara, Takuo

Mizoi, Kenta; Arakawa, Hiroshi; Yano, Kentaro; Koyama, Satoshi; Kojima, Hajime; Ogihara, Takuo.

Afiliación

Mizoi K; Faculty of Pharmacy, Takasaki University of Health and Welfare, 60, Nakaorui-machi, Takasaki, Gunma 370-0033, Japan.
Arakawa H; Faculty of Pharmacy, Takasaki University of Health and Welfare, 60, Nakaorui-machi, Takasaki, Gunma 370-0033, Japan.
Yano K; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan.
Koyama S; Faculty of Pharmacy, Takasaki University of Health and Welfare, 60, Nakaorui-machi, Takasaki, Gunma 370-0033, Japan.
Kojima H; Faculty of Pharmacy, Yokohama University of Pharmacy, 601, Matano-cho, Totsuka-ku, Yokohama, Kanagawa 245-0066, Japan.
Ogihara T; Faculty of Pharmacy, Takasaki University of Health and Welfare, 60, Nakaorui-machi, Takasaki, Gunma 370-0033, Japan.

Biomedicines ; 8(10)2020 Sep 23.

Article en En | MEDLINE | ID: mdl-32977664

Palabras clave

3D culture; CYP induction; drug-induced liver injury; metabolism; pharmacokinetics; primary human hepatocyte; spheroids; toxicity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Biomedicines Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza

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