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Dissecting Brainstem Locomotor Circuits: Converging Evidence for Cuneiform Nucleus Stimulation.
Chang, Stephano J; Cajigas, Iahn; Opris, Ioan; Guest, James D; Noga, Brian R.
Afiliación
  • Chang SJ; Neuroscience Graduate Program, University of Miami Miller School of Medicine, Miami, FL, United States.
  • Cajigas I; The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United States.
  • Opris I; Division of Neurosurgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada.
  • Guest JD; The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United States.
  • Noga BR; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United States.
Front Syst Neurosci ; 14: 64, 2020.
Article en En | MEDLINE | ID: mdl-32973468
There are a pressing and unmet need for effective therapies for freezing of gait (FOG) and other neurological gait disorders. Deep brain stimulation (DBS) of a midbrain target known as the pedunculopontine nucleus (PPN) was proposed as a potential treatment based on its postulated involvement in locomotor control as part of the mesencephalic locomotor region (MLR). However, DBS trials fell short of expectations, leading many clinicians to abandon this strategy. Here, we discuss the potential reasons for this failure and review recent clinical data along with preclinical optogenetics evidence to argue that another nearby nucleus, the cuneiform nucleus (CnF), may be a superior target.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Syst Neurosci Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Syst Neurosci Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza