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A link between appendectomy and gastrointestinal cancers: a large-scale population-based cohort study in Korea.
Park, Youn Young; Lee, Kil-Yong; Oh, Seong Taek; Park, Sang Hyun; Han, Kyung Do; Lee, Jaeim.
Afiliación
  • Park YY; Division of Coloproctology, Department of Surgery, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Cheonbo-ro 271, Uijeongbu-si, Gyeonggi-do, 11765, Republic of Korea.
  • Lee KY; Division of Coloproctology, Department of Surgery, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Cheonbo-ro 271, Uijeongbu-si, Gyeonggi-do, 11765, Republic of Korea.
  • Oh ST; Division of Coloproctology, Department of Surgery, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Cheonbo-ro 271, Uijeongbu-si, Gyeonggi-do, 11765, Republic of Korea.
  • Park SH; Department of Medical Statistics, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
  • Han KD; Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.
  • Lee J; Division of Coloproctology, Department of Surgery, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Cheonbo-ro 271, Uijeongbu-si, Gyeonggi-do, 11765, Republic of Korea. lji96@catholic.ac.kr.
Sci Rep ; 10(1): 15670, 2020 09 24.
Article en En | MEDLINE | ID: mdl-32973258
An association between appendectomy and subsequent gastrointestinal (GI) cancer development has been postulated, although the evidence is limited and inconsistent. To provide clarification, we investigated the link between appendectomy and GI cancers in a large nationwide appendectomy cohort. This cohort was derived from the claims database of the National Health Insurance Service in South Korea and comprised 158,101 patients who had undergone appendectomy between 2007 and 2014. A comparison cohort of 474,303 subjects without appendectomy was selected after 1:3 matching by age and sex. The incidence of GI cancers after appendectomy was observed, and risk factors for GI cancers were determined by using a multivariable-adjusted proportional hazards model. Appendectomy did not significantly increase the incidence of GI cancers in the overall population (1.529 and 1557 per 1000 person-years in the non-appendectomy and appendectomy cohorts, respectively). However, appendectomy significantly increased the incidence of GI cancers in subgroups consisting of elderly (≥ 60 years) patients (adjusted HR, 1.102; 95% confidence interval, 1.011-1.201; p = 0.028) or women (adjusted HR, 1.180; 95% confidence interval, 1.066-1.306; p = 0.001).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apendicectomía / Neoplasias Gastrointestinales Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apendicectomía / Neoplasias Gastrointestinales Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido