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Syndecan-4 as a Marker of Endothelial Dysfunction in Patients with Resistant Hypertension.
Lipphardt, Mark; Dihazi, Hassan; Maas, Jens-Holger; Schäfer, Ann-Kathrin; Amlaz, Saskia I; Ratliff, Brian B; Koziolek, Michael J; Wallbach, Manuel.
Afiliación
  • Lipphardt M; Department of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, 37073 Göttingen, Germany.
  • Dihazi H; Department of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, 37073 Göttingen, Germany.
  • Maas JH; Department of Transfusion Medicine, Göttingen University Medical Center, Georg August University, 37073 Göttingen, Germany.
  • Schäfer AK; Department of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, 37073 Göttingen, Germany.
  • Amlaz SI; Department of Cardiology and Pneumology, Göttingen University Medical Center, Georg August University, 37073 Göttingen, Germany.
  • Ratliff BB; Renal Research Institute and Departments of Medicine, Pharmacology, and Physiology, New York Medical College, Valhalla, NY 10595, USA.
  • Koziolek MJ; Department of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, 37073 Göttingen, Germany.
  • Wallbach M; Department of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, 37073 Göttingen, Germany.
J Clin Med ; 9(9)2020 Sep 22.
Article en En | MEDLINE | ID: mdl-32971813
(1) Background: Arterial hypertension (HTN) is one of the most relevant cardiovascular risk factors. Nowadays multiple pharmaceutical treatment options exist with novel interventional methods (e.g., baroreflex activation therapy (BAT)) as a last resort to treat patients with resistant HTN. Although pathophysiology behind resistant HTN is still not fully understood. There is evidence that selected biomarkers may be involved in the pathophysiology of HTN. (2) Methods: We investigated serum SDC4-levels in patients suffering from resistant HTN before and 6 months after BAT implantation. We collected 19 blood samples from patients with resistant HTN and blood pressure above target and measured serum SDC4-levels. (3) Results: Our results showed high serum SDC4-levels in patients with resistant HTN as compared to a healthy population. Patients with both, resistant HTN and diabetes mellitus type II, demonstrated higher serum SDC4-levels. ß-blockers had lowering effects on serum SDC4-levels, whereas calcium channel blockers were associated with higher levels of serum SDC4. BAT implantation did not lead to a significant difference in serum SDC4-levels after 6 months of therapy. (4) Conclusion: Based on our results we propose SDC4 is elevated in patients suffering from resistant HTN. Thus, SDC4 might be a potential marker for endothelial dysfunction in patients with resistant hypertension.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Clin Med Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Clin Med Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza