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Bortezomib-Loaded Mesoporous Silica Nanoparticles Selectively Alter Metabolism and Induce Death in Multiple Myeloma Cells.
Nigro, Alessandra; Frattaruolo, Luca; Fava, Mariarosa; De Napoli, Ilaria; Greco, Marianna; Comandè, Alessandra; De Santo, Marzia; Pellegrino, Michele; Ricci, Elena; Giordano, Francesca; Perrotta, Ida; Leggio, Antonella; Pasqua, Luigi; Sisci, Diego; Cappello, Anna Rita; Morelli, Catia.
Afiliación
  • Nigro A; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
  • Frattaruolo L; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
  • Fava M; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
  • De Napoli I; Department of Environmental Engineering, University of Calabria, 87036 Rende, Italy.
  • Greco M; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
  • Comandè A; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
  • De Santo M; Department of Environmental Engineering, University of Calabria, 87036 Rende, Italy.
  • Pellegrino M; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
  • Ricci E; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
  • Giordano F; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
  • Perrotta I; Department of Biology, Ecology and Earth Sciences, Centre for Microscopy and Microanalysis (CM2), Transmission Electron Microscopy Laboratory, University of Calabria, Rende, 87036 Cosenza, Italy.
  • Leggio A; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
  • Pasqua L; Department of Environmental Engineering, University of Calabria, 87036 Rende, Italy.
  • Sisci D; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
  • Cappello AR; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
  • Morelli C; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
Cancers (Basel) ; 12(9)2020 Sep 21.
Article en En | MEDLINE | ID: mdl-32967380
A mesoporous silica-based nanodevice bearing the antineoplastic drug bortezomib (BTZ), whose release is triggered in acidic environment and grafted with folic acid (FOL) as a targeting function (FOL-MSN-BTZ) was tested on folate receptor overexpressing (FR+) multiple myeloma (MM) cells and on FR negative (FR-) normal cells. FOL-MSN-BTZ efficacy studies were conducted by means of growth experiments, TEM, TUNEL assay and Western Blotting analysis (WB). Metabolic investigations were performed to assess cells metabolic response to MSNs treatments. FOL-MSN-BTZ exclusively killed FR+ MM cells, leading to an apoptotic rate that was comparable to that induced by free BTZ, and the effect was accompanied by metabolic dysfunction and oxidative stress. Importantly, FOL-MSN-BTZ treated FR- normal cells did not show any significant sign of injury or metabolic perturbation, while free BTZ was still highly toxic. Notably, the vehicle alone (MSN-FOL) did not affect any biological process in both tested cell models. These data show the striking specificity of FOL-MSN-BTZ toward FR+ tumor cells and the outstanding safety of the MSN-FOL vehicle, paving the way for a future exploitation of FOL-MSN-BTZ in MM target therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza